PDF(Pubmed)
Abstract：
A 23-subject feasibility study is reported to assess how UV absorbance measurements on exhaled breath samples collected from silicon microreactors can be used to detect COVID-19. The silicon microreactor technology chemoselectively preconcentrates exhaled carbonyl volatile organic compounds and subsequent methanol elution provides samples for analysis. The underlying scientific rationale that viral infection will induce an increase in exhaled carbonyls appears to be supported by the results of the feasibility study. The data indicate statistically significant differences in measured UV absorbance values between healthy and symptomatic COVID-19 positive subjects in the wavelength range from 235 nm to 305 nm. Factors such as subject age were noted as potential confounding variables.
摘要：
据报道，一项由23个主题进行的可行性研究旨在评估如何使用从硅微反应器收集的呼出气样本的紫外线吸光度测量来检测COVID-19。硅微反应器技术化学选择性预浓缩呼出的羰基VOC，随后的甲醇洗脱提供了用于分析的样品。可行性研究的结果似乎支持了病毒感染会导致呼出气羰基增加的基本科学原理。数据表明，在235nm至305nm的波长范围内，健康和有症状的COVID-19阳性受试者之间测得的紫外线吸收值存在统计学上的显着差异。受试者年龄等因素被认为是潜在的混杂变量。
