背景:异雌激素是合成或天然存在的化学物质,由于其与内源性激素的分子相似性,能够改变人和动物的内分泌系统。关于它们对妇女健康的影响的数据有限。慢性暴露于外源性雌激素可促进雌激素相关疾病的发展。
目的:为了检查子宫肌瘤或子宫内膜异位症患者与对照女性之间的异种雌激素浓度(TEXB-α)差异,并研究这些患者的临床和社会人口统计学特征与其异雌激素水平之间的关系。
方法:前瞻性病例对照研究。我们选择了221名在2017年至2021年之间在Quironsalud马德里大学医院接受手术的女性。这些病例包括117例患者:74例接受子宫平滑肌瘤手术的妇女,21子宫内膜异位症,和22两种病理。对照组包括104名健康女性,她们因其他原因接受了外科手术。在所有患者的网膜脂肪中测定TEXB-α。使用问卷并查看患者的医疗记录,我们收集了社会人口统计数据和其他相关变量.
结果:绝大多数研究参与者(68.8%)具有可检测水平的异种雌激素。我们发现网膜脂肪中的TEXB-α水平与肌瘤或子宫内膜异位症之间没有关联。在案例组中,在马德里社区生活或工作的妇女展出,平均而言,3.12EeqpM/gTEXB-α水平高于其他领域的工作水平(p=0.030)。提到使用含雌激素的激素避孕药的妇女,平均而言,3.02EeqpM/g的TEXB-α水平高于从未使用过的人(p=0.022)。
结论:本研究发现网膜异种雌激素水平与平滑肌瘤或子宫内膜异位症之间没有关联。然而,它们在大多数参与者中的存在及其与高度污染地区的联系强调了限制环境暴露于这些物质的重要性。我们还确定了激素避孕药使用与异雌激素浓度之间的关联。
BACKGROUND: Xenoestrogens are synthetic or naturally occurring chemicals capable of altering the endocrine system of humans and animals owing to their molecular similarity to endogenous hormones. There is limited data regarding their effects on women´s health. Chronic exposure to xenoestrogens can promote the development of estrogen-related diseases.
OBJECTIVE: To examine xenoestrogen concentration (TEXB-α) differences between women with leiomyomas or endometriosis and control women, and to study the relationship between the clinical and sociodemographic characteristics of these patients and their xenoestrogen levels.
METHODS: Prospective
case-control study. We selected 221 women who underwent surgery at Quironsalud Madrid University Hospital between 2017 and 2021. The cases included 117 patients: 74 women who underwent surgery for uterine leiomyomas, 21 with endometriosis, and 22 with both pathologies. The control group comprised 104 healthy women who underwent surgical procedures for other reasons. TEXB-α was determined in the omental fat of all patients. Using a questionnaire and reviewing the patients\' medical records, we collected sociodemographic data and other relevant variables.
RESULTS: A significant majority of study participants (68.8%) had detectable levels of xenoestrogens. We found no association between TEXB-α levels in omental fat and the presence of myomas or endometriosis. In the
case group, women living or working in Madrid Community exhibited, on average, 3.12 Eeq pM/g higher levels of TEXB-α compared to those working in other areas (p = 0.030). Women who referred to the use of estrogen-containing hormonal contraceptives had, on average, 3.02 Eeq pM/g higher levels of TEXB-α than those who had never used them (p = 0.022).
CONCLUSIONS: This study found no association between omental xenoestrogen levels and leiomyomas or endometriosis. However, their presence in most participants and their association with highly polluted areas emphasizes the importance of limiting environmental exposure to these substances. We also identified an association between hormonal contraceptive use and xenoestrogen concentration.