背景:越来越多的证据表明,环境因素可能在胃食管癌(GOC)的发展中起重要作用,然而,微量元素对GOC的影响尚不清楚。
目的:评估微量元素对GOC的影响以及其他因素对GOC的影响。
方法:在泰兴进行的一项基于人群的病例对照研究中,从GOC病例和对照中收集头发和指甲样本,中国,用电感耦合等离子体质谱法检测12种微量元素的浓度。在调整其他因素后,使用非条件逻辑回归模型计算与GOC相关的12种微量元素浓度的比值比(ORs)和95%置信区间(CIs)。
结果:共包括830个头发样本(581个对照和249个病例)和895个指甲样本(559个对照和336个病例)。与最低三分浓度相比,钙的三元率较高,Zn,Fe,Al,Cr,Pb,Se,V与GOC呈正相关,而镁的三元率较高,Mn,Sr,和As与GOC呈负相关。头发Cr水平与其他两个危险因素之间的显着相互作用,包括吸烟(相互作用的P=0.044)和饮酒(相互作用的P=0.028),观察到与GOC相关。
结论:当前的研究表明,头发和指甲中的这12种微量元素与GOC有不同程度的关联。需要进一步的研究和动物实验来澄清这些关联并探索潜在的机制。
UNASSIGNED:微量元素在胃食管癌(GOC)发展或抑制中的作用尚不清楚。在这项研究中,我们在泰兴进行的一项基于人群的病例对照研究中,进一步探讨了12种微量元素与GOC之间的关系,中国。钙含量较高,Zn,Fe,Al,Cr,Pb,Se,和V与GOC升高呈正相关,而较高水平的镁之间的逆关联,Mn,Sr,As,并观察到GOC。观察到的关联在头发和指甲样品中是一致的。此外,确定了头发Cr水平与吸烟或饮酒之间的交互作用。
Growing evidence suggests that environmental factors probably play important roles in the development of gastroesophageal cancers (GOC), however, the effects of trace elements on GOC remain unclear.
To assess the effect of trace elements on GOC and the effect modification by other factors.
Hair and fingernail samples were collected from GOC cases and controls in a population-based
case-control study in Taixing, China, and were used to detect the concentrations of 12 trace elements using inductively coupled plasma mass spectrometry. Unconditional logistic regression models were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for concentrations of 12 trace elements in association with GOC after adjusting the other factors.
A total of 830 hair samples (581 controls and 249 cases) and 895 fingernail samples (559 controls and 336 cases) were included. Compared to the lowest-tertile concentration, the higher tertiles of Ca, Zn, Fe, Al, Cr, Pb, Se, and V were positively associated with GOC, while the higher tertiles of Mg, Mn, Sr, and As were inversely associated with GOC. Significant interactions between the hair level of Cr and two other risk factors, including smoking (P for interaction = 0.044) and alcohol drinking (P for interaction = 0.028), were observed in association with GOC.
The current study reveals that these 12 trace elements in hair and fingernails are associated with GOC to varying degrees. Further studies and animal experiments are needed to clarify the associations and explore potential mechanisms.
The role of trace elements in the development or inhibition of gastroesophageal cancers (GOC) remains unclear. In this study, we further explored the associations between 12 trace elements and GOC based on a population-based
case-control study conducted in Taixing, China. Higher levels of Ca, Zn, Fe, Al, Cr, Pb, Se, and V were positively associated with increased GOC, while inverse associations between higher levels of Mg, Mn, Sr, As, and GOC were observed. Observed associations were consistent in hair and fingernail samples. Moreover, interaction effects between hair level of Cr and smoking or alcohol drinking were identified.