背景:与贝叶斯大脑假设一致,通过聚焦镇痛选择试验(FAST)获得的疼痛强度报告的受试者内部变异性可能是升高的有害信号确定性的替代指标.非疼痛相关任务的结果,橡胶手的错觉,被假设为反映相同的结构。这项研究旨在探讨疼痛强度报告的变异性与橡胶手错觉的结果之间的受试者内部差异是否相关。
方法:非临床参与者在同步(实验)和异步(对照)条件下进行了经典的橡胶手错觉。评估了两个结果:本体感受漂移和所有权感。此后,参与者接受FAST检查,以评估受热刺激时疼痛报告的受试者内部变异性.组内相关性(ICC)和相关系数(R2)是主要结果。Spearman的相关性被用来评估两个任务的结果之间的关联。
结果:36名志愿者完成了这项研究。FAST结果ICC(Spearmanr=0.355,p=0.033)和R2(Spearmanr=0.349,p=0.037)均与同步而非异步条件下的本体感受漂移呈正相关(p>0.05)。所有权的主观感觉和FAST结果不相关(p>0.05)。
结论:两个任务结果之间的关联意味着两个任务至少部分评估了相似的结构。目前的知识表明,这种结构代表了人在感知上升的感觉信号时的确定性,或者,在贝叶斯术语中,可能性的确定性。
Consistent with the Bayesian brain hypothesis, the within-subject variability of pain intensity
reports as captured with the Focused Analgesia Selection Test (FAST) might be a surrogate measure of the certainty in ascending noxious signals. The outcomes of a non-pain-related task, the rubber hand illusion, were hypothesized to reflect the same construct. This study aimed to explore whether within-subject differences in variability of pain intensity
reports and the outcomes of the rubber hand illusion might be related.
Nonclinical participants underwent the classic rubber hand illusion under synchronous (experimental) and asynchronous (control) conditions. Two outcomes were assessed: proprioceptive drift and feeling of ownership. Thereafter, participants underwent the FAST to assess the within-subject variability of pain
reports in response to heat stimuli. Intraclass correlation (ICC) and the correlation coefficient (R2) were the main outcomes. Spearman\'s correlations were used to assess associations between the outcomes of the 2 tasks.
Thirty-six volunteers completed the study. Both FAST outcomes-ICC (Spearman\'s r = 0.355, p = 0.033) and R2 (Spearman\'s r = 0.349, p = 0.037)-were positively correlated with proprioceptive drift in the synchronous but not asynchronous conditions (p > 0.05). The subjective feeling of ownership and FAST outcomes did not correlate (p > 0.05).
The associations between the 2 tasks\' outcomes imply that both tasks at least partly assess similar constructs. Current knowledge suggests that this construct represents the person\'s certainty in perceiving ascending sensory signals, or, in Bayesian terminology, the certainty of the likelihood.