纳米技术通过引入有效递送药物的创新方法,显著改变了癌症治疗。这篇文献综述深入分析了纳米载体在癌症治疗中的作用。特别关注隐身效应的关键概念。隐形效应是指纳米载体逃避免疫系统和克服生理障碍的能力。该评论调查了各种纳米载体的设计和组成,如脂质体,胶束,和无机纳米粒子,强调表面改性和功能化的重要性。免疫系统之间复杂的相互作用,调理,吞噬作用,并检查了蛋白质电晕以了解隐形效应。审查仔细评估了增强隐身效果的策略,包括聚合物表面涂层,仿生伪装,和靶向配体。隐形纳米载体的体内行为及其对药代动力学的影响,生物分布,和毒性也进行了系统检查。此外,这篇综述介绍了临床应用,批准的基于纳米载体的癌症治疗的案例研究,和临床试验中的新兴配方。该领域的未来方向和障碍,例如纳米载体工程的进步,个性化纳米医学,监管方面的考虑,和道德含义,进行了详细讨论。该综述总结了主要发现,并强调了隐形纳米载体在彻底改变癌症治疗方面的变革潜力。这篇综述通过提供对先进研究的见解,增强了对基于纳米载体的癌症疗法及其潜在影响的理解。临床应用,和监管方面的考虑。
Nanotechnology has significantly transformed cancer treatment by introducing innovative methods for delivering drugs effectively. This literature
review provided an in-depth analysis of the role of nanocarriers in cancer therapy, with a particular focus on the critical concept of the \'stealth effect.\' The stealth effect refers to the ability of nanocarriers to evade the immune system and overcome physiological barriers. The
review investigated the design and composition of various nanocarriers, such as liposomes, micelles, and inorganic nanoparticles, highlighting the importance of surface modifications and functionalization. The complex interaction between the immune system, opsonization, phagocytosis, and the protein corona was examined to understand the stealth effect. The
review carefully evaluated strategies to enhance the stealth effect, including surface coating with polymers, biomimetic camouflage, and targeting ligands. The in vivo behavior of stealth nanocarriers and their impact on pharmacokinetics, biodistribution, and toxicity were also systematically examined. Additionally, the
review presented clinical applications, case studies of approved nanocarrier-based cancer therapies, and emerging formulations in clinical trials. Future directions and obstacles in the field, such as advancements in nanocarrier engineering, personalized nanomedicine, regulatory considerations, and ethical implications, were discussed in detail. The review concluded by summarizing key findings and emphasizing the transformative potential of stealth nanocarriers in revolutionizing cancer therapy. This
review enhanced the comprehension of nanocarrier-based cancer therapies and their potential impact by providing insights into advanced studies, clinical applications, and regulatory considerations.