Mesh : Vanadates / pharmacology chemistry Cerium / pharmacology chemistry Tissue Distribution Prospective Studies Nanoparticles / chemistry

来  源:   DOI:10.1039/d3tb01786a

Abstract:
Cerium vanadate nanoparticles (CeVO4 NPs), which are members of the rare earth orthovanadate nanomaterial family, have generated considerable interest due to their diverse properties and prospective biomedical applications. The current study, which provides a comprehensive overview of the synthesis and characterization techniques for CeVO4 NPs, emphasizes the sonochemical method as an efficient and straightforward technique for producing CeVO4 NPs with tunable size and shape. This paper investigates the toxicity and biocompatibility of CeVO4 NPs, as well as their antioxidant and catalytic properties, which allow them to modify the redox state of biological systems and degrade organic pollutants. In addition, the most recent developments in the medicinal applications of CeVO4 NPs, such as cancer treatment, antibacterial activity, biosensing, and drug or gene delivery, are emphasized. In addition, the disadvantages of CeVO4 NPs, such as stability, aggregation, biodistribution, and biodegradation, are outlined, and several potential solutions are suggested. The research concludes with data and recommendations for developing and enhancing CeVO4 NPs in the biomedical industry.
摘要:
钒酸铈纳米颗粒(CeVO4NPs),它们是原钒酸稀土纳米材料家族的成员,由于其多样化的特性和未来的生物医学应用,已经引起了相当大的兴趣。目前的研究,其中全面概述了CeVO4NP的合成和表征技术,强调声化学方法是生产尺寸和形状可调的CeVO4NP的有效和直接的技术。本文研究了CeVO4NPs的毒性和生物相容性,以及它们的抗氧化和催化性能,这使得它们能够改变生物系统的氧化还原状态并降解有机污染物。此外,CeVO4NPs药用应用的最新进展,比如癌症治疗,抗菌活性,生物传感,和药物或基因传递,强调。此外,CeVO4NPs的缺点,比如稳定性,聚合,生物分布,和生物降解,概述,并提出了几种潜在的解决方案。该研究最后提供了在生物医学行业开发和增强CeVO4NPs的数据和建议。
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