血栓性静脉炎是以一个或多个血管阻塞为特征的炎性病症,通常在腿部,由于血凝块的形成。据报道,中药,包括脉络宁注射液,对于治疗炎症和血液疾病是有利的。这项研究评估了脉络宁注射液治疗啮齿动物血栓性静脉炎的疗效。以及研究其对纤维蛋白溶解的影响,炎症,和凝结。通过改良的结扎技术在啮齿动物中建立了血栓性静脉炎的实验装置。5组动物:假手术组,模型组,和三个脉络宁治疗组(低,中等,和高剂量)。疼痛反应,水肿,凝血参数(PT,APTT,TT,FIB),血清炎症标志物(IL-6,TNF-α,CRP),并评估内皮标志物(ICAM-1,VCAM-1,NF-κB)的表达水平。通过测量血液流变学参数和TXB2、ET的浓度进一步评估血流和血管功能。和6-k-PGF1α。与假手术组相比,模型组内皮表达水平显著增加,凝血潜伏期,和炎症标志物(p<0.05)。邮寄的管理,特别是在高剂量和中等剂量,导致炎症标志物的大幅减少,凝血参数的增强,抑制ICAM-1和VCAM-1表达,和血液流变学测量值恢复至基线(p<0.05)。高剂量组6-k-PGF1α浓度明显较高,TXB2和ET水平较低,提示促血栓因子和抗血栓因子恢复平衡.脉络宁注射液在血栓性静脉炎大鼠模型中的应用具有显着的治疗效果。这种效果通过缓解疼痛表现出来,炎症减少,增强血液粘度和促进纤维蛋白溶解。研究表明,脉络宁注射液可以作为血栓性静脉炎的可行治疗选择,由于其抗炎和血流增强特性,可能有助于改善伤口愈合。
Thrombophlebitis is the inflammatory condition characterized by obstruction of one or more vessels, commonly in the legs, due to the formation of blood clots. It has been reported that traditional Chinese medicine, including Mailuoning injection, is advantageous for treating inflammatory and blood disorders. This research assessed the therapeutic efficacy of Mailuoning injection in the treatment of
thrombophlebitis in rodents, as well as investigated its impact on fibrinolysis, inflammation, and coagulation. An experimental setup for
thrombophlebitis was established in rodents via modified ligation technique. Five groups comprised the animals: sham operation group, model group, and three Mailuoning treatment groups (low, medium, and high dosages). The pain response, edema, coagulation parameters (PT, APTT, TT, FIB), serum inflammatory markers (IL-6, TNF-α, CRP), and expression levels of endothelial markers (ICAM-1, VCAM-1, NF-κB) were evaluated. Blood flow and vascular function were further assessed by measuring hemorheological parameters and the concentrations of TXB2, ET, and 6-k-PGF1α. In contrast to the sham group, model group demonstrated statistically significant increases in endothelial expression levels, coagulation latencies, and inflammatory markers (p < 0.05). The administration of mailing, specifically at high and medium dosages, resulted in a substantial reduction in inflammatory markers, enhancement of coagulation parameters, suppression of ICAM-1 and VCAM-1 expression, and restoration of hemorheological measurements to baseline (p < 0.05). Significantly higher concentrations of 6-k-PGF1α and lower levels of TXB2 and ET were observed in high-dose group, suggesting that pro- and anti-thrombotic factors were restored to equilibrium. Utilization of Mailuoning injection in rat model of
thrombophlebitis exhibited significant therapeutic impact. This effect was manifested through pain alleviation, diminished inflammation, enhanced blood viscosity and facilitation of fibrinolysis. The
study indicated that Mailuoning injection may serve as a viable therapeutic option for
thrombophlebitis, potentially aiding in the improvement of wound healing by virtue of its anti-inflammatory and blood flow-enhancing characteristics.