PDF(Pubmed)
Abstract：
UNASSIGNED: Thrombocytopenia is commonly associated with infectious diseases and serves as an indicator of disease severity. However, reports on its manifestation in conjunction with Klebsiella pneumoniae liver abscess (KPLA) are scarce. The present study sought to elucidate the correlation between thrombocytopenia and KPLA severity and delve into the etiological factors contributing to the incidence of thrombocytopenia.
UNASSIGNED: A retrospective analysis of the clinical data from patients with KPLA admitted between June 2012 and June 2023 was performed. Baseline characteristics, biochemical assessments, therapeutic interventions, complications, and clinical outcomes were compared between patients with and without thrombocytopenia. To investigate the potential etiologies underlying thrombocytopenia, the association between platelet count reduction and thrombophlebitis was examined, with a particular focus on platelet consumption. Furthermore, bone marrow aspiration results were evaluated to assess platelet production anomalies.
UNASSIGNED: A total of 361 KPLA patients were included in the study, among whom 60 (17%) had concurrent thrombocytopenia. Those in the thrombocytopenia group exhibited significantly higher rates of thrombophlebitis (p = 0.042), extrahepatic metastatic infection (p = 0.01), septic shock (p = 0.024), admissions to the intensive care unit (p = 0.002), and in-hospital mortality (p = 0.045). Multivariate analysis revealed that thrombocytopenia (odds ratio, 2.125; 95% confidence interval, 1.114-4.056; p = 0.022) was independently associated with thrombophlebitis. Among the thrombocytopenic patients, eight underwent bone marrow aspiration, and six (75%) had impaired medullar platelet production. After treatment, 88.6% of thrombocytopenic patients (n = 47) demonstrated recovery in their platelet counts with a median recovery time of five days (interquartile range, 3-6 days).
UNASSIGNED: Thrombocytopenia in patients with KPLA is indicative of increased disease severity. The underlying etiologies for thrombocytopenia may include impaired platelet production within the bone marrow and augmented peripheral platelet consumption as evidenced by the presence of thrombophlebitis.
UNASSIGNED: A retrospective analysis of the clinical data from patients with KPLA admitted between June 2012 and June 2023 was performed. Baseline characteristics, biochemical assessments, therapeutic interventions, complications, and clinical outcomes were compared between patients with and without thrombocytopenia. To investigate the potential etiologies underlying thrombocytopenia, the association between platelet count reduction and thrombophlebitis was examined, with a particular focus on platelet consumption. Furthermore, bone marrow aspiration results were evaluated to assess platelet production anomalies.
UNASSIGNED: A total of 361 KPLA patients were included in the study, among whom 60 (17%) had concurrent thrombocytopenia. Those in the thrombocytopenia group exhibited significantly higher rates of thrombophlebitis (p = 0.042), extrahepatic metastatic infection (p = 0.01), septic shock (p = 0.024), admissions to the intensive care unit (p = 0.002), and in-hospital mortality (p = 0.045). Multivariate analysis revealed that thrombocytopenia (odds ratio, 2.125; 95% confidence interval, 1.114-4.056; p = 0.022) was independently associated with thrombophlebitis. Among the thrombocytopenic patients, eight underwent bone marrow aspiration, and six (75%) had impaired medullar platelet production. After treatment, 88.6% of thrombocytopenic patients (n = 47) demonstrated recovery in their platelet counts with a median recovery time of five days (interquartile range, 3-6 days).
UNASSIGNED: Thrombocytopenia in patients with KPLA is indicative of increased disease severity. The underlying etiologies for thrombocytopenia may include impaired platelet production within the bone marrow and augmented peripheral platelet consumption as evidenced by the presence of thrombophlebitis.
摘要：
■血小板减少症通常与感染性疾病相关，并可作为疾病严重程度的指标。然而,关于其与肺炎克雷伯菌肝脓肿（KPLA）一起表现的报道很少。本研究旨在阐明血小板减少症与KPLA严重程度之间的相关性，并深入研究导致血小板减少症发生率的病因。
■对2012年6月至2023年6月收治的KPLA患者的临床数据进行了回顾性分析。基线特征，生化评估，治疗性干预措施,并发症,比较有和无血小板减少症患者的临床结局.为了调查潜在的血小板减少症的病因，检查了血小板计数减少与血栓性静脉炎之间的关联，特别关注血小板消耗。此外，评估骨髓穿刺结果以评估血小板生成异常.
■总共361名KPLA患者被纳入研究，其中60人(17%)并发血小板减少症.血小板减少组的血栓性静脉炎发生率明显增高(p=0.042),肝外转移感染（p=0.01），感染性休克（p=0.024），重症监护室入院(p=0.002)，和住院死亡率（p=0.045）。多因素分析显示血小板减少(比值比，2.125；95%置信区间，1.114-4.056；p=0.022）与血栓性静脉炎独立相关。在血小板减少症患者中,八人接受了骨髓穿刺,和6（75％）有髓血小板产生受损。治疗后,88.6%的血小板减少症患者（n=47）显示血小板计数恢复，中位恢复时间为5天（四分位距，3-6天）。
■KPLA患者的血小板减少表明疾病严重程度增加。血小板减少症的潜在病因可能包括骨髓内血小板产生受损和外周血小板消耗增加，如血栓性静脉炎的存在所证明。
■对2012年6月至2023年6月收治的KPLA患者的临床数据进行了回顾性分析。基线特征，生化评估，治疗性干预措施,并发症,比较有和无血小板减少症患者的临床结局.为了调查潜在的血小板减少症的病因，检查了血小板计数减少与血栓性静脉炎之间的关联，特别关注血小板消耗。此外，评估骨髓穿刺结果以评估血小板生成异常.
■总共361名KPLA患者被纳入研究，其中60人(17%)并发血小板减少症.血小板减少组的血栓性静脉炎发生率明显增高(p=0.042),肝外转移感染（p=0.01），感染性休克（p=0.024），重症监护室入院(p=0.002)，和住院死亡率（p=0.045）。多因素分析显示血小板减少(比值比，2.125；95%置信区间，1.114-4.056；p=0.022）与血栓性静脉炎独立相关。在血小板减少症患者中,八人接受了骨髓穿刺,和6（75％）有髓血小板产生受损。治疗后,88.6%的血小板减少症患者（n=47）显示血小板计数恢复，中位恢复时间为5天（四分位距，3-6天）。
■KPLA患者的血小板减少表明疾病严重程度增加。血小板减少症的潜在病因可能包括骨髓内血小板产生受损和外周血小板消耗增加，如血栓性静脉炎的存在所证明。
