MicroRNA(miRNA/miR)代表一类内源性、包含约22个核苷酸的短链非编码RNA分子。具体来说,miR-325位于X染色体短臂上的区域2的第一子带内。值得注意的是,已在各种肿瘤系统中观察到miR-325的异常表达,跨越紧张,内分泌,呼吸,生殖系统和消化系统。miR-325表现出靶向至少20个蛋白质编码基因的能力,从而影响不同的细胞过程,包括细胞增殖,上皮-间质转化,凋亡,入侵和迁移。此外,miR-325在六个竞争性内源性RNA(ceRNA)调节轴的形成中起关键作用,涉及一个环状RNA,四个长链非编码RNA和一个额外的miRNA。通过基因打靶参与各种信号通路,miR-325的异常表达与不同癌症患者的临床病理状况有关,显着影响患者的临床病理和预后。此外,miR-325与奥沙利铂耐药性的发展有关,顺铂和阿霉素在癌细胞中的作用。它参与这些药物的抗癌分子机制强调了它在治疗环境中的潜在意义。然而,值得注意的是,目前的研究并未专门针对基于性别的细胞系选择.总之,本综述提供了有关miR-325的相关发现的全面总结,为未来专注于确定与该miRNA相关的分子机制的研究工作提供了有价值的见解.
MicroRNA (miRNA/miR) represents a category of endogenous, short-chain non-coding RNA molecules comprising ~22 nucleotides. Specifically, miR-325 is situated within the first sub-band of region 2 on the short arm of the X chromosome. Notably, aberrant expression of miR-325 has been observed across various tumor systems, spanning the nervous, endocrine, respiratory, reproductive and digestive systems. miR-325 exhibits the capacity to target a minimum of 20 protein-coding genes, thereby influencing diverse cellular processes, including cell proliferation, epithelial-mesenchymal transition, apoptosis, invasion and migration. Moreover, miR-325 serves a pivotal role in the formation of six competing endogenous RNA (ceRNA) regulatory axes, involving one circular RNA, four long non-coding RNA and one additional miRNA. By participating in various signaling pathways through gene targeting, the abnormal expression of miR-325 has been associated with clinicopathological conditions in diverse patients with cancer, significantly impacting both the clinicopathology and prognosis of affected individuals. Additionally, miR-325 has been associated with the development of resistance to oxaliplatin, cisplatin and doxorubicin in cancer cells. Its involvement in the anticancer molecular mechanisms of these agents underscores its potential significance in therapeutic contexts. However, it is noteworthy that the current study did not specifically address sex-based cell line selection. In conclusion, the present
review provides a comprehensive summary of the relevant findings concerning miR-325, offering valuable insights for future research endeavors focused on determining the molecular mechanisms associated with this miRNA.