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Abstract：
Stroke is a severe neurological disease that is associated with high rates of morbidity and mortality, and the underlying pathological processes are complex. Ferroptosis fulfills a significant role in the progression and treatment of stroke. It is well established that ferroptosis is a type of programmed cell death that is distinct from other forms or types of cell death. The process of ferroptosis involves multiple signaling pathways and regulatory mechanisms that interact with mechanisms inherent to stroke development. Inducers and inhibitors of ferroptosis have been shown to exert a role in the onset of this cell death process. Furthermore, it has been shown that interfering with ferroptosis affects the occurrence of stroke, indicating that targeting ferroptosis may offer a promising therapeutic approach for treating patients of stroke. Hence, the present review aimed to summarize the latest progress that has been made in terms of using therapeutic interventions for ferroptosis as treatment targets in cases of stroke. It provides an overview of the relevant pathways and molecular mechanisms that have been investigated in recent years, highlighting the roles of inducers and inhibitors of ferroptosis in stroke. Additionally, the intervention potential of various types of Traditional Chinese Medicine is also summarized. In conclusion, the present review provides a comprehensive overview of the potential therapeutic targets afforded by ferroptosis‑associated pathways in stroke, offering new insights into how ferroptosis may be exploited in the treatment of stroke.
摘要：
中风是一种严重的神经系统疾病，与高发病率和死亡率有关。潜在的病理过程是复杂的。Ferroptosis在中风的进展和治疗中发挥重要作用。众所周知，铁死亡是一种程序性细胞死亡，不同于其他形式或类型的细胞死亡。铁死亡的过程涉及与中风发展固有机制相互作用的多个信号通路和调节机制。已显示铁凋亡的诱导剂和抑制剂在该细胞死亡过程的开始中起作用。此外，已经表明，干扰铁中毒会影响中风的发生，这表明靶向铁性凋亡可能为治疗卒中患者提供一种有希望的治疗方法。因此，本综述旨在总结在脑卒中患者中使用铁性凋亡的治疗干预措施作为治疗目标方面取得的最新进展。概述了近年来研究的相关途径和分子机制,强调铁凋亡的诱导剂和抑制剂在中风中的作用。此外,总结了各类中药的干预潜力。总之,本综述全面概述了铁凋亡相关途径在中风中提供的潜在治疗靶点，提供了关于如何利用铁性凋亡治疗中风的新见解。
