呋塞米和氨茶碱/茶碱联合在儿科患者中的利尿作用尚不清楚。这项系统评价的主要目的是研究在儿科人群中,与单独使用呋塞米相比,同时使用呋塞米和氨茶碱/茶碱的临床利尿作用(尿量和液体平衡)。OvidMEDLINE,中部,和EMBASE从开始至2022年3月进行了观察性研究和随机对照试验(RCT),比较了呋塞米与呋塞米和氨茶碱/茶碱在儿科人群中的给药.病例报告,案例系列,评论,给编辑的信,系统评价,荟萃分析被排除。本系统综述包括五篇文章,样本总数为187名患者。与单独的呋塞米相比,我们的汇总数据表明,呋塞米和氨茶碱/茶碱的联合给药与较高的尿量相关(平均差异:2.91[90%CI1.54至4.27],p<0.0001,I2=90%)和更负的流体平衡(平均差-28.27[95%CI:-46.21至-10.33],p=0.002,I2=56%)比单独接受呋塞米的人。
结论:本文首次总结了儿科人群中呋塞米与氨茶碱/茶碱联合使用的证据。我们的系统评价表明,呋塞米和氨茶碱/茶碱的共同给药可能比单独的呋塞米在小儿液体超负荷患者中产生更好的尿量利尿作用和液体负平衡。鉴于异质性的严重程度和证据的低水平,有必要在未来进行足够有效的试验,以提供关于在儿科人群中联合使用氨茶碱/茶碱和呋塞米作为利尿剂的证据.
背景:•液体超负荷与重症监护病房儿童的不良预后有关。•单独使用呋塞米的无效结果,即使是高剂量,作为利尿剂用于重症监护病房利尿剂耐药液体超负荷的儿童。
背景:•这是比较单独使用呋塞米以及呋塞米和氨茶碱/茶碱共同给药的第一个系统综述。•与单独使用呋塞米相比,本文显示了呋塞米和氨茶碱/茶碱促进尿量和液体负平衡的潜在益处。
The diuretic effect of the combined furosemide and aminophylline/
theophylline among pediatric patients remains unclear. The primary aim of this systematic
review was to examine the clinical diuretic effects (urine output and fluid balance) of co-administration of furosemide and aminophylline/theophylline as compared to furosemide alone in pediatric population. Ovid MEDLINE, CENTRAL, and EMBASE were searched from its inception until March 2022 for observational studies and randomized controlled trials (RCTs) comparing the administration of furosemide versus furosemide and aminophylline/theophylline in pediatric population. Case reports, case series, commentaries, letters to editors, systematic reviews, and meta-analyses were excluded. Five articles with a total sample population of 187 patients were included in this systematic
review. As compared to the furosemide alone, our pooled data demonstrated that co-administration of furosemide and aminophylline/theophylline was associated with higher urine output (mean difference: 2.91 [90% CI 1.54 to 4.27], p < 0.0001, I2 = 90%) and a more negative fluid balance (mean difference - 28.27 [95% CI: - 46.21 to - 10.33], p = 0.002, I2 = 56%) than those who received furosemide alone.
CONCLUSIONS: This is the first paper summarizing the evidence of combined use of furosemide with aminophylline/theophylline in pediatric population. Our systematic
review demonstrated that the co-administration of furosemide and aminophylline/
theophylline could potentially yield better diuretic effects of urine output and negative fluid balance than furosemide alone in pediatric patients with fluid overload. Given the substantial degree of heterogeneity and low level of evidence, future adequately powered trials are warranted to provide evidence regarding the combined use of aminophylline/theophylline and furosemide as diuretic in the pediatric population.
BACKGROUND: • Fluid overload is associated with poor prognosis for children in the intensive care unit. • The ineffective result of furosemide alone, even at high dose, as diuretic agent for children with diuretic resistant fluid overload in the intensive care unit.
BACKGROUND: • This is the first systematic
review that compares furosemide alone and co-administration of furosemide and aminophylline/theophylline. • This paper showed potential benefit of co-administration of furosemide and aminophylline/theophylline promoting urine output and negative fluid balance compared to furosemide alone.