在这份报告中,我们介绍了一名诊断为非梗阻性无精子症(NOA)的男性患者的临床治疗,一种特征是由于精子发生受损而导致射精中缺乏精子的病症。一名37岁的患者接受了两种外科手术:睾丸精子抽吸术(TESA)和经皮附睾精子抽吸术(PESA)。令人惊讶的是,随后的β-人绒毛膜促性腺激素(β-HCG)检测产生了有希望的结果,提示NOA综合征可能是可逆的.茶碱和己酮可可碱,具有免疫调节作用的磷酸二酯酶抑制剂,在本案例研究中创造性地用于增加PESA后的精子活力和活化。透明质酸也被用作额外的疗法,因为众所周知它有助于精子发育和与卵母细胞结合。病人接受了透明质酸治疗,这可能会增加受精率并改善精子的选择。这个深入的案例研究提供了关于通过结合茶碱有效管理NOA的有见地的信息,己酮可可碱,和透明质酸。结果突出了这些疗法恢复精子发生的能力,提供治疗男性不育的尖端方法。需要更多的研究来阐明潜在的过程,并确认该策略在更成功的生殖医学疗法中的有效性。
In this report, we present the clinical management of a male patient diagnosed with non-obstructive azoospermia (NOA), a condition characterized by the absence of sperm in the ejaculate due to impaired spermatogenesis. A 37-year-old patient underwent two surgical procedures: testicular sperm aspiration (TESA) and percutaneous epididymal sperm aspiration (PESA). Surprisingly, the beta-human chorionic gonadotropins (β-HCG) testing that followed produced promising findings suggesting NOA syndrome may be reversible.
Theophylline and pentoxifylline, phosphodiesterase inhibitors with immunomodulatory effects, were creatively used in this
case study to increase sperm viability and activation after PESA. Hyaluronic acid was also used as an additional therapy because it is well known for aiding in sperm development and binding to oocytes. The patient underwent hyaluronic acid, which can potentially increase the fertilization rate and improve the selection of sperm. This in-depth
case study offers insightful information on the effective management of NOA by combining
theophylline, pentoxifylline, and hyaluronic acid. The results highlight the ability of these therapies to revive spermatogenesis, offering a cutting-edge method of treating male infertility. More research is required to clarify the underlying processes and confirm the effectiveness of this strategy in more successful reproductive medicine therapies.