PDF(Pubmed)
Abstract：
UNASSIGNED: Theophylline has been used for decades in human medicine for its psychostimulant, anti-inflammatory, and bronchodilator effects. Historically, in pulmonary medicine, theophylline has been used in the treatment of obstructive pulmonary diseases such as bronchial asthma (BA) or chronic obstructive pulmonary disease (COPD). This review aims to determine whether theophylline still has its place in the therapy of obstructive pulmonary diseases or whether we can even extend its use to other diagnoses such as atropine-resistant cardiac arrests, apnea of prematurity, or others. Moreover, we also aim to determine if there is a rationale for using low-dose theophylline due to its immunomodulatory and anti-inflammatory effect, or if the future of methylxanthines lies in newly synthesized derivates of theophylline such as bamifylline, or doxofylline.
UNASSIGNED: The narrative review is based on a literature search of the articles indexed in the PubMed database in 2023. We searched the database since the year 2009 using the MeSH terms \"theophylline\", \"aminophylline\", and \"methylxanthines\" and we included original articles in the English language.
UNASSIGNED: Theophylline has a number of adverse drug reactions (ADRs), the most serious of which is its effect on the cardiovascular system. It can cause severe arrhythmias or even cardiac arrest when overdosed. On the other hand, there is still a substantial amount of its applications in current clinical practice.
UNASSIGNED: There is considerable controversy associated with its use in current medicine, which can be attributed both to its narrow therapeutic range and its mentioned cardiotoxic effect. Herein, we summarize the current state-of-art of theophylline and its use in human medicine.
UNASSIGNED: The narrative review is based on a literature search of the articles indexed in the PubMed database in 2023. We searched the database since the year 2009 using the MeSH terms \"theophylline\", \"aminophylline\", and \"methylxanthines\" and we included original articles in the English language.
UNASSIGNED: Theophylline has a number of adverse drug reactions (ADRs), the most serious of which is its effect on the cardiovascular system. It can cause severe arrhythmias or even cardiac arrest when overdosed. On the other hand, there is still a substantial amount of its applications in current clinical practice.
UNASSIGNED: There is considerable controversy associated with its use in current medicine, which can be attributed both to its narrow therapeutic range and its mentioned cardiotoxic effect. Herein, we summarize the current state-of-art of theophylline and its use in human medicine.
摘要：
■茶碱因其精神兴奋剂而在人类医学中使用了数十年，抗炎,和支气管扩张剂的影响。历史上,在肺医学中，茶碱已用于治疗阻塞性肺疾病，例如支气管哮喘（BA）或慢性阻塞性肺疾病（COPD）。这篇综述旨在确定茶碱是否仍然在阻塞性肺疾病的治疗中占有一席之地，或者我们是否甚至可以将其使用扩展到其他诊断，如阿托品抗性心脏骤停，早产儿呼吸暂停,或其他人。此外，我们还旨在确定是否有理由使用低剂量茶碱，由于其免疫调节和抗炎作用，或者，如果甲基黄嘌呤的未来在于茶碱的新合成衍生物，如巴米可可碱，或者多索茶碱.
■叙述性评论基于对2023年PubMed数据库中索引的文章的文献检索。自2009年以来，我们使用MeSH术语“茶碱”搜索了数据库，“氨茶碱”，和“甲基黄嘌呤”，我们用英语收录了原始文章。
■茶碱有许多药物不良反应（ADR），其中最严重的是它对心血管系统的影响。过量服用可引起严重的心律失常甚至心脏骤停。另一方面,目前在临床实践中仍有大量的应用。
■其在当前医学中的使用存在相当大的争议，这可以归因于其狭窄的治疗范围和所提到的心脏毒性作用。在这里，我们总结了茶碱的最新技术及其在人类医学中的应用。
■叙述性评论基于对2023年PubMed数据库中索引的文章的文献检索。自2009年以来，我们使用MeSH术语“茶碱”搜索了数据库，“氨茶碱”，和“甲基黄嘌呤”，我们用英语收录了原始文章。
■茶碱有许多药物不良反应（ADR），其中最严重的是它对心血管系统的影响。过量服用可引起严重的心律失常甚至心脏骤停。另一方面,目前在临床实践中仍有大量的应用。
■其在当前医学中的使用存在相当大的争议，这可以归因于其狭窄的治疗范围和所提到的心脏毒性作用。在这里，我们总结了茶碱的最新技术及其在人类医学中的应用。
