UNASSIGNED: The narrative review is based on a literature search of the articles indexed in the PubMed database in 2023. We searched the database since the year 2009 using the MeSH terms \"theophylline\", \"aminophylline\", and \"methylxanthines\" and we included original articles in the English language.
UNASSIGNED: Theophylline has a number of adverse drug reactions (ADRs), the most serious of which is its effect on the cardiovascular system. It can cause severe arrhythmias or even cardiac arrest when overdosed. On the other hand, there is still a substantial amount of its applications in current clinical practice.
UNASSIGNED: There is considerable controversy associated with its use in current medicine, which can be attributed both to its narrow therapeutic range and its mentioned cardiotoxic effect. Herein, we summarize the current state-of-art of theophylline and its use in human medicine.
■叙述性评论基于对2023年PubMed数据库中索引的文章的文献检索。自2009年以来,我们使用MeSH术语“茶碱”搜索了数据库,“氨茶碱”,和“甲基黄嘌呤”,我们用英语收录了原始文章。
■茶碱有许多药物不良反应(ADR),其中最严重的是它对心血管系统的影响。过量服用可引起严重的心律失常甚至心脏骤停。另一方面,目前在临床实践中仍有大量的应用。
■其在当前医学中的使用存在相当大的争议,这可以归因于其狭窄的治疗范围和所提到的心脏毒性作用。在这里,我们总结了茶碱的最新技术及其在人类医学中的应用。