钙钛矿太阳能电池由于其高功率转换效率而显示出作为可再生能源的潜力。然而,关于钙钛矿对人类健康和生态系统的潜在影响的理解有限。在这项研究中,两组雄性Wistar白化病大鼠接受了35次钙钛矿复合材料注射,剂量为0.372mg/kg体重。这些动物接受了彻底的检查,包括形态计量学,血液学,生物化学,组织学,和行为分析。肝脏,肾,和睾丸活检进行了处理和组织学检查。此外,两组小鼠(钙钛矿处理和对照小鼠,每个n=10)都接受了三项行为测试:零迷宫高架测试,大理石掩埋试验,和明暗盒子测试。钙钛矿处理的大鼠显示天冬氨酸转氨酶水平显着增加,丙氨酸氨基转移酶,碱性磷酸酶,甘油三酯,胆固醇,肌酐,血尿素氮,白细胞,和血小板。然而,总胆红素水平下降,白蛋白值无明显变化。此外,暴露于钙钛矿复合材料导致乳酸脱氢酶和红细胞计数略有下降。组织病理学检查显示肝积水变性,枯否细胞肥大和增生,和肾脏水肿变性,而睾丸组织未受影响。此外,在钙钛矿处理的小鼠中观察到行为变化,包括抑郁症,焦虑,强迫性埋葬活动。这些发现表明,暴露于钙钛矿可以导致显著的血液和生化变化,以及肝肾组织病理学改变和行为改变。此外,长期暴露于钙钛矿材料可能会导致重要器官的结构和功能改变。
Perovskite solar cells display potential as a renewable energy source because of their high-power conversion efficiency. However, there is limited understanding regarding the potential impact of perovskite on human health and the ecosystem. In this
study, two sets of male Wistar albino rats received 35 injections of perovskite composite at a dosage of 0.372 mg/kg body weight. The animals underwent thorough examinations, encompassing morphometric, hematological, biochemical, histological, and behavioral analyses. Liver, kidney, and testis biopsies were processed and examined histologically. Additionally, two groups of mice (perovskite-treated and control mice, each with n = 10) underwent three behavioral tests: the Elevated Zero Maze test, Marble Burying test, and Light-Dark Box test. Perovskite-treated rats displayed a significant increase in levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglycerides, cholesterol, creatinine, blood urea nitrogen, white blood cells, and platelets. However, total bilirubin levels decreased, with no significant alteration in albumin values. Furthermore, exposure to perovskite composite resulted in a slight decrease in lactate dehydrogenase and red blood cell count. Histopathological examination revealed hepatic hydropic degeneration, Kupffer cells hypertrophy and hyperplasia, and renal hydropic degeneration, while testicular tissues remained unaffected. Moreover, behavioral changes were observed in perovskite-treated mice, including depression, anxiety, and compulsive burying activity. These findings suggest that exposure to perovskite can lead to significant hematological and biochemical changes, as well as hepatorenal histopathological alterations and behavioral changes. Additionally, chronic exposure to perovskite materials may induce structural and functional alterations in vital organs.