精神压力,一种难以识别和描述的人类共同情感,会引起严重的心理障碍。皮肤和汗液是容易获得的生物标志物和生物信号来源,其中包含有关精神压力的信息。对于当前的可穿戴设备而言,以非侵入性方式实时监测心理压力是具有挑战性的。因此,我们开发了一款集成有汗液皮质醇传感器和心率变化(HRV)传感器的智能手表。这款智能手表可以长时间实时记录汗液中的皮质醇水平和HRV指数。利用普鲁士蓝(PB)掺杂的分子印迹聚合物(MIP)修饰的栅电极制造了基于有机电化学晶体管(OECT)的皮质醇传感器。传感器信号电流会随着汗液皮质醇的结合而降低,由于PBMIP导电路径的阻塞,表现出良好的灵敏度,选择性,和稳定性。HRV传感器通过光电体积描记术方法制造。我们已经将两个传感器集成到可穿戴的智能手表中,可以与手机APP和上位机软件进行很好的匹配。通过使用这个智能手表,我们观察到,在短期压力环境中,汗液中的皮质醇水平与HRV指数呈负相关.我们的研究在实时和非侵入性监测人类的压力水平方面取得了很大进展,这不仅促进了压力管理,还有更好的心理学研究。
Mental stress, a human\'s common emotion that is difficult to recognize and describe, can give rise to serious psychological disorders. Skin and
sweat are easily accessible sources of biomarkers and bio-signals that contain information about mental stress. It is challenging for current wearable devices to monitor psychological stress in real-time with a non-invasive manner. Therefore, we have developed a smartwatch integrated with a
sweat cortisol sensor and a heart rate variation (HRV) sensor. This smartwatch can simultaneously record the cortisol levels in
sweat and HRV index in real time over a long period. The cortisol sensors based on organic electrochemical transistor (OECT) are fabricated by utilizing the Prussian-blue (PB) doped molecular imprinting polymer (MIP) modified gate electrode. The sensor signal current will decrease following the combination of
sweat cortisol, due to the blocking of the PBMIP conductive path, demonstrating good sensitivity, selectivity, and stability. The HRV sensor is manufactured by a photoplethysmography method. We have integrated the two sensors into a wearable smartwatch that can match well with the mobile phone APP and the upper computer software. Through the use of this smartwatch, we have observed a negative correlation between cortisol levels in
sweat and the HRV index in short-term stressful environments. Our research presents a great progress in real-time and non-invasive monitoring human\'s stress levels, which promotes not only the stress management, but also better psychological research.