背景:羧基疗法的总体效果,定义为二氧化碳的管理,已经研究了很多年了。有人建议通过改善氧合,与组织灌注调节器相互作用,破坏脂肪细胞膜,该方法可以在不同的美学和病理条件下导致显着改善。因此,我们旨在系统地回顾现有的研究,这些研究评估了羧基疗法在皮肤病学疾病中的潜在益处,以及它如何客观地反对科学审查。
方法:我们搜索了PubMed,Scopus,Embase,和WebofScience数据库,包括探索该方法在治疗任何皮肤病方面的功效的研究。
结果:共确定了27项研究(合并样本超过700例),其中大部分是临床试验。面部皱纹,眶周色素沉着,皮肤松弛缺乏,疤痕,茎纹,局部脂肪分解和脂肪团,脱发,慢性糖尿病伤口,和银屑病斑块包括所研究的皮肤病学条件的包装。除了一些研究,该方法主要在所有提到的条件下表现出显著的改进。术中和术后不良事件均为轻度和暂时性,包括红斑,疼痛,Crepitus,和瘀斑。
结论:羧基疗法可以为该领域的实践人员提供可持续的良好结果。然而,研究该方法的减脂能力并经历不同程度复发的病例数量引起了我们的注意.此外,我们观察到研究中使用的结局指标之间存在显著差异.每种情况下的适度样本量也增加了伤害,因为评估该方法的条件在一般人群中相当普遍。因此,一个明确的结论,需要开展更多的随机对照试验,这些试验的缺点得到了很好的解决.
BACKGROUND: The overall effects of Carboxytherapy, defined as the administration of carbon dioxide, have been studied for many years. It has been suggested that by improving oxygenation, interacting with the tissue perfusion regulators, and disrupting the adipose cell membranes, the method can lead to notable improvements in different esthetic and pathological conditions. Therefore, we aimed to systematically
review the available studies evaluating the potential benefits of carboxytherapy in dermatological conditions and how it objectively stands against scientific scrutiny.
METHODS: We searched the PubMed, Scopus, Embase, and Web of Science databases, including the studies exploring the method\'s efficacy in managing any dermatological condition.
RESULTS: A total 27 of studies were identified (with a pooled sample of over 700 cases), most of which were clinical trials. Facial wrinkles, periorbital hyperpigmentation, skin laxity deficiency, scars, striae distensae, localized lipolysis and cellulite, alopecia, chronic diabetic wounds, and psoriatic plaques comprised the package of the dermatological conditions that were studied. Except for a few studies, the method mainly demonstrated significant improvements on all of the mentioned conditions. The inter- and post-operational adverse events were mild and transient, including erythema, pain, crepitus, and ecchymoses.
CONCLUSIONS: Carboxytherapy can provide those practicing in the field with sustainably favorable results. However, the numbers of cases on whom the fat-reducing capabilities of the method were studied and experienced varying degrees of recurrence caught our eye. In addition, we observed a notable disparity between the outcome measures utilized in the studies. The modest sample size in each condition also added to the injury, as the conditions on which the method was evaluated are pretty common in the general population. Therefore, for a definite conclusion, more randomized controlled trials with the shortcomings mentioned well addressed need to be conducted.