OBJECTIVE: (1) To assess the efficacy and safety of different treatment options reported for striae and (2) to determine the most efficient treatment options for each subtype of striae.
METHODS: A systematic search was performed on MEDLINE, Embase, and PubMed with no publication date or language restrictions. All articles with original data and treatment outcomes were included.
RESULTS: One hundred fifty-one studies on the treatment of striae met inclusion criteria (83% female, mean age at diagnosis = 30.2), and 4,806 treatment outcomes of striae were described. Energy-based devices were the most reported modality (56%; n = 2,699/4,806), followed by topicals (19%; n = 919/4,806) and combinations (12%; n = 567/4,806). The highest rates of complete response were injection-based devices for striae distensae (7%; n = 12/172), CO 2 lasers for striae alba (4%; n = 12/341), and platelet-rich plasma injections for striae rubra (31%; n = 4/13).
CONCLUSIONS: Treatment options for striae are varied, likely indicating a lack of effective treatments due to the diversity in striae subtypes. Improved outcomes in striae management may be achieved with additional research on factors that predict treatment response.
目的:(1)评估针对纹状体报告的不同治疗方案的疗效和安全性,以及(2)确定每种纹状体亚型的最有效治疗方案。
方法:对MEDLINE进行了系统搜索,Embase,和PubMed,没有发布日期或语言限制。包括所有具有原始数据和治疗结果的文章。
结果:一百五十一项关于纹治疗的研究符合纳入标准(83%为女性,诊断时的平均年龄=30.2),并描述了4,806例纹状体的治疗结果。基于能量的设备是报告最多的模态(56%;n=2,699/4,806),其次是局部药物(19%;n=919/4,806)和组合(12%;n=567/4,806)。完全缓解率最高的是基于注射的横纹装置(7%;n=12/172),用于白纹的CO2激光器(4%;n=12/341),和富含血小板的血浆注射治疗皱纹纹(31%;n=4/13)。
结论:纹的治疗方案多种多样,可能表明由于纹状体亚型的多样性,缺乏有效的治疗方法。通过对预测治疗反应的因素进行额外的研究,可以改善纹管理的结果。