双酚AF(BPAF),双酚A(BPA)的类似物,常见于制造业,以其内分泌干扰特性而闻名。尽管与BPA的不良反应有潜在的相似性,特定于BPAF及其对男性生殖生理的影响的毒理学数据有限。这篇小型综述旨在阐明BPAF对男性生殖系统的影响,关注雌激素效应,对下丘脑-垂体-性腺(HPG)轴的影响,类固醇生成,精子发生,和跨代生殖毒性。此外,我们概述了目前对BPAF诱导的男性生殖障碍潜在机制的见解.BPAF暴露,直接或母系,与对男性生殖功能的有害影响有关,包括对睾丸屏障(BTB)结构的破坏,类固醇生成的中断,睾丸功能障碍,肛门生殖器距离减少(AGD),精子和精液质量的缺陷。机械上,HPG轴基因表达改变,类固醇生成途径的缺陷,芳香化酶途径的激活,活性氧(ROS)诱导的级联效应,ERK信号的激活,和免疫反应共同导致BPAF对男性生殖系统的不利影响。鉴于男性生殖问题和不育症的患病率很高,随着双酚广泛的环境分布,这项研究为BPAF的负面影响提供了有价值的见解。研究结果强调了考虑安全使用这种化合物的重要性,敦促进一步探索和监管关注,以减少与BPAF暴露相关的潜在风险。
Bisphenol AF (BPAF), an analogue of bisphenol A (BPA), is commonly found in manufacturing industries and known for its endocrine-disrupting properties. Despite potential similarities in adverse effects with BPA, limited toxicological data exist specifically for BPAF and its impact on male reproductive physiology. This mini-
review aims to elucidate the influence of BPAF on the male reproductive system, focusing on estrogenic effects, effects on the hypothalamus-pituitary-gonad (HPG) axis,
steroidogenesis, spermatogenesis, and transgenerational reproductive toxicity. Additionally, we outline the current insights into the potential mechanisms underlying BPAF-induced male reproductive disorders. BPAF exposure, either directly or maternally, has been associated with detrimental effects on male reproductive functions, including damage to the blood-testis barrier (BTB) structure, disruptions in
steroidogenesis, testis dysfunction, decreased anogenital distance (AGD), and defects in sperm and semen quality. Mechanistically, altered gene expression in the HPG axis, deficits in the
steroidogenesis pathway, activation of the aromatase pathway, cascade effects induced by reactive oxygen species (ROS), activation of ERK signaling, and immunological responses collectively contribute to the adverse effects of BPAF on the male reproductive system. Given the high prevalence of male reproductive issues and infertility, along with the widespread environmental distribution of bisphenols, this study provides valuable insights into the negative effects of BPAF. The findings underscore the importance of considering the safe use of this compound, urging further exploration and regulatory attention to decrease potential risks associated with BPAF exposure.