Scandinavian and Nordic Countries

斯堪的纳维亚和北欧国家
  • 文章类型: Journal Article
    大多数接受手术切除的胰腺癌患者最终会出现疾病复发。本研究旨在调查是否有证据支持胰腺癌手术后的常规监测,次要目的是分析北欧国家监测战略的实施情况。
    进行了范围审查,以确定全球临床实践指南和与胰腺癌切除术后监测相关的研究。随后,对来自四个北欧国家的20个胰腺单位进行了一项调查,以评估他们目前对手术患者进行随访的做法。
    共纳入16项临床实践指南和17项研究。该指南对胰腺癌术后监测提供了不一致的建议。临床研究数据主要基于回顾性队列研究,证据水平低,未解决前置时间偏差。瑞典和丹麦建议积极监测,但不在挪威超过手术/辅助期。芬兰没有关于监测的国家建议。北欧调查显示,不同单位之间的报告实践差异很大。大约75%(20个单位中的15个)进行了常规的术后监测。作为监测的一部分,80%使用常规CA19-9检测,67%使用常规CT。约73%的中心持续随访至术后5年。
    胰腺癌手术后常规长期(即5年)监测的证据仍然有限。北欧国家的大多数胰腺单位进行定期随访,但是协议各不相同。
    UNASSIGNED: Most patients with pancreatic cancer who have undergone surgical resection eventually develop disease recurrence. ‍This study aimed to investigate whether there is evidence to support routine surveillance after pancreatic cancer surgery, with a secondary aim of analyzing the implementation of surveillance strategies in the Nordic countries.
    UNASSIGNED: A scoping review was conducted to identify clinical practice guidelines globally and research studies relating to surveillance after pancreatic cancer resection. This was followed by a survey among 20 pancreatic units from four Nordic countries to assess their current practice of follow-up for operated patients.
    UNASSIGNED: Altogether 16 clinical practice guidelines and 17 research studies were included. The guidelines provided inconsistent recommendations regarding postoperative surveillance of pancreatic cancer. The clinical research data were mainly based on retrospective cohort studies with low level of evidence and lead-time bias was not addressed. Active surveillance was recommended in Sweden and Denmark, but not in Norway beyond the post-operative/adjuvant period. Finland had no national recommendations for surveillance. The Nordic survey revealed a wide variation in reported practice among the different units. About 75% (15 of 20 units) performed routine postoperative surveillance. Routine CA 19-9 testing was used by 80% and routine CT by 67% as part of surveillance. About 73% of centers continued follow-up until 5 years postoperatively.
    UNASSIGNED: Evidence for routine long-term (i.e. 5 years) surveillance after pancreatic cancer surgery remains limited. Most pancreatic units in the Nordic countries conduct regular follow-up, but protocols vary.
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  • 文章类型: Journal Article
    背景:肌肉减少症和肌肉减少性肥胖(SO)是与年龄相关的综合征,可能损害老年人的身心健康。北欧国家在疾病流行方面与其他地区不同,生活方式的行为,和预期寿命,这可能会影响肌肉减少症和SO的患病率。因此,本研究的目的是回顾北欧国家在该领域的现有证据和差距.
    方法:PubMed,Embase,截至2023年2月,搜索了WebofScience(WOS)。此外,检索纳入研究的灰色文献和参考文献列表.两名独立研究人员评估了论文并提取了数据。
    结果:在6,363项搜索研究中,有33项研究被纳入本范围综述。肌肉减少症的总体患病率从0.9%到58.5%不等。当考虑定义标准和设置时,社区居住的老年人仍然存在广泛的患病率范围。SO的患病率从4%到11%不等,根据这一领域的唯一研究。根据纳入的研究,肌少症的潜在危险因素包括营养不良,低体力活动,特定疾病(例如,糖尿病),炎症,多药,和衰老,而增加体力活动水平和改善饮食摄入可能会降低少肌症的风险.少数可用的肌肉减少症干预措施主要集中在有/无营养补充剂的阻力训练(例如,蛋白质,维生素D)。
    结论:我们的研究结果表明,对SO的研究不足,但对肌少症的研究数量呈上升趋势。然而,大多数纳入的研究都有描述性的横断面设计,小样本量,并应用不同的诊断标准。因此,需要遵循统一的最新指南的大型精心设计的队列研究,才能全面了解北欧国家这两种与年龄相关的医疗状况,并制定相应的预防/治疗计划。
    BACKGROUND: Sarcopenia and sarcopenic obesity (SO) are age-related syndromes that may compromise physical and mental health among older adults. The Nordic countries differ from other regions on prevalence of disease, life-style behavior, and life expectancy, which may impact prevalence of sarcopenia and SO. Therefore, the aim of this study is to review the available evidence and gaps within this field in the Nordic countries.
    METHODS: PubMed, Embase, and Web of science (WOS) were searched up to February 2023. In addition, grey literature and reference lists of included studies were searched. Two independent researcher assessed papers and extracted data.
    RESULTS: Thirty-three studies out of 6,363 searched studies were included in this scoping review. Overall prevalence of sarcopenia varied from 0.9 to 58.5%. A wide prevalence range was still present for community-dwelling older adults when definition criteria and setting were considered. The prevalence of SO ranged from 4 to 11%, according to the only study on this field. Based on the included studies, potential risk factors for sarcopenia include malnutrition, low physical activity, specific diseases (e.g., diabetes), inflammation, polypharmacy, and aging, whereas increased levels of physical activity and improved dietary intake may reduce the risk of sarcopenia. The few available interventions for sarcopenia were mainly focused on resistance training with/without nutritional supplements (e.g., protein, vitamin D).
    CONCLUSIONS: The findings of our study revealed inadequate research on SO but an increasing trend in the number of studies on sarcopenia. However, most of the included studies had descriptive cross-sectional design, small sample size, and applied different diagnostic criteria. Therefore, larger well-designed cohort studies that adhere to uniform recent guidelines are required to capture a full picture of these two age-related medical conditions in Nordic countries, and plan for prevention/treatment accordingly.
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  • 文章类型: Review
    在过去的十年里,北欧国家针对人口老龄化采取了政策战略。政府行动必须根据其效力进行评估。本文的目的是确定和审查北欧国家北极地区与年龄包容的室外空间有关的政策。我们的分析重点是针对芬兰老年人的中央政府白皮书,挪威,瑞典,和冰岛。对此类政策文件的审查提供了对老年人和健康老龄化的主要理解的见解。此外,这种分析可能会发现国家政策中的“盲点”,特别是关于研究稀疏的最北端和农村北极地区。我们的结果表明,政策文件中如何解决北欧北极地区的老年人口及其进入室外空间的问题。我们发现除了少数例外,北极农村的老年人在北欧国家政府文件中明显缺席。此外,对室外空间的访问是笼统地提到的,以及北极农村环境的具体挑战,比如恶劣的气候,漫长的冬季和地理距离没有得到解决。注意到的遗漏可能是“城乡”的结果,\"南北\",“室内-室外”,和“泛化”偏见。
    In the last decade, policy strategies were adopted in response to population ageing in the Nordic countries. Governmental actions have to be evaluated in terms of their efficacy. The objective of this article is to identify and review the policies related to age-inclusive outdoor spaces in the Arctic regions of Nordic countries. Our analysis focuses on central government white papers that address the older adults in Finland, Norway, Sweden, and Iceland. A review of such policy documents provides insights into the predominant understandings of older adults and healthy ageing. Moreover, such analysis may identify \"blind spots\" in the national policies, especially regarding the sparsely researched northernmost and rural Arctic territories. Our results demonstrate how the older populations in the Nordic Arctic and their access to outdoor spaces are addressed in the policy documents. We found that with few exceptions, the older people of the rural Arctic is strikingly absent in the Nordic national governmental papers. Moreover, access to outdoor spaces is mentioned in general terms, and specific challenges of the rural Arctic context, such as the harsh climate, long winters and geographical distances are not addressed. The noticed omissions might be the result of \"urban-rural\", \"south-north\", \"indoor-outdoor\", and \"generalisation\" biases.
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  • 文章类型: Journal Article
    背景:本范围审查的目的是总结和描述北欧国家基于人群的身体活动和久坐时间研究的方法和结果(丹麦,芬兰,冰岛,挪威,和瑞典),并于2000年或更晚出版。
    方法:2023年6月在PubMed和WebofScience中使用预定义的搜索词进行了系统搜索。
    结果:确定了十四个独特的研究项目或监测研究。此外,包括国家机构发布的2项监测研究,共纳入16项研究。芬兰和挪威都有国家监测系统,定期对学龄儿童/青少年和成人进行调查。在丹麦,最近仅在学童中收集了具有全国代表性的数据。到目前为止,瑞典没有使用基于设备的数据收集的常规国家监测系统。冰岛没有发现任何研究。第一项研究是在2001年进行的,最近的一项研究是在2022年进行的,大部分数据是从2016年至今收集的。五项研究包括6-18岁的儿童/青少年,没有一项研究包括学龄前儿童。总共有11项研究包括成年人,其中8个也涵盖了老年人。没有专门针对老年人的研究。分析样本量范围从205到27,890。提出了详细的方法,例如关于抽样策略的信息,设备类型和位置,磨损协议,和身体活动分类方案。儿童/青少年的身体活动水平和久坐时间,成年人,以及北欧国家的老年人。
    结论:在北欧国家越来越多地实施基于设备的人群对身体活动和久坐行为的监测。各种各样的设备,placement,北欧国家内部和之间的数据程序突出了在比较研究结果以及需要更标准化的数据收集方面的挑战。
    OBJECTIVE: The purpose of this scoping review was to summarize and describe the methodology and results from population-based studies of physical activity and sedentary time measured with devices in the Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) and published in 2000 or later.
    METHODS: A systematic search was carried out in PubMed and Web of Science in June 2023 using predefined search terms.
    RESULTS: Fourteen unique research projects or surveillance studies were identified. Additionally, 2 surveillance studies published by national agencies were included, resulting in a total of 16 studies for inclusion. National surveillance systems exist in Finland and Norway, with regular survey waves in school-aged children/adolescents and adults. In Denmark, recent nationally representative data have been collected in school children only. So far, Sweden has no regular national surveillance system using device-based data collection. No studies were found from Iceland. The first study was conducted in 2001 and the most recent in 2022, with most data collected from 2016 to date. Five studies included children/adolescents 6-18 years, no study included preschoolers. In total 11 studies included adults, of which 8 also covered older adults. No study focused specifically on older adults. The analytical sample size ranged from 205 to 27,890. Detailed methodology is presented, such as information on sampling strategy, device type and placement, wear protocols, and physical activity classification schemes. Levels of physical activity and sedentary time in children/adolescents, adults, and older adults across the Nordic countries are presented.
    CONCLUSIONS: A growing implementation of device-based population surveillance of physical activity and sedentary behavior in the Nordic countries has been identified. The variety of devices, placement, and data procedures both within and between the Nordic countries highlights the challenges when it comes to comparing study outcomes as well as the need for more standardized data collection.
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  • 文章类型: Systematic Review
    背景:北欧或波罗的海饮食是一种健康的植物性饮食模式,由源自北欧国家的食物组成,与地中海饮食密切相关。已经发现坚持地中海饮食与虚弱的风险降低有关。虽然坚持北欧饮食与健康益处有关,人们对它与脆弱的联系知之甚少。
    目的:调查观察性研究中关于北欧/波罗的海饮食与老年人虚弱之间关联的证据。
    方法:系统评价。
    方法:三个数据库(Medline/Ovid,Embase/Ovid,和Scopus)在2023年2月进行了系统搜索,以进行观察性研究,以检查≥60岁成年人中坚持北欧饮食与虚弱之间的关系。两位作者独立评估了研究资格和偏倚风险的论文全文。
    结果:3项研究(6篇论文报告了结果)符合纳入标准,其中一项研究(2篇论文)仅包括女性。通过改良的Fried标准(一项研究),对北欧饮食的坚持与女性的虚弱风险降低有关。此外,更坚持北欧饮食与改善肌肉(手握/腿)力量(一项研究)和身体表现(两项研究)有关,但是这些差异只出现在女性身上,在两项研究中,男性没有显著结果。对北欧饮食的更高依从性还与行动限制的风险降低和执行自我护理任务的能力提高(一项研究)以及日常生活活动的边界非显着差异(一项研究)有关。由于结果异质性,未进行荟萃分析。虽然所有的研究都是高质量的,由于方法上的限制,结果应仔细解释.
    结论:坚持北欧饮食在降低虚弱风险方面可能是有希望的,但需要更有力的性别代表性和脆弱的特定结局研究.
    BACKGROUND: The Nordic or Baltic Sea diet is a healthy plant-based dietary pattern composed of foods originating from Nordic countries, closely related to the Mediterranean diet. Adherence to the Mediterranean diet has been found to be associated with a reduced risk of frailty. Although adherence to the Nordic diet has been associated with health benefits, little is known about its association with frailty.
    OBJECTIVE: To investigate the evidence from observational studies regarding the association between the Nordic/Baltic Sea diet and frailty among older adults.
    METHODS: Systematic review.
    METHODS: Three databases (Medline/Ovid, Embase/Ovid, and Scopus) were systematically searched in February 2023 for observational studies examining the association between adherence to the Nordic diet and frailty among adults ≥60 years. The two authors independently assessed the full text of the papers for eligibility of studies and risk of bias.
    RESULTS: Three studies (the results of which were reported across 6 papers) met the inclusion criteria, among which one study (2 papers) included only women. Greater adherence to the Nordic diet was associated with a reduced risk of frailty measured by modified Fried criteria in women (one study). Moreover, greater adherence to the Nordic diet was associated with improved muscle (handgrip/leg) strength (one study) and physical performance (two studies), but these differences were seen only in women, with no significant results in men in two studies. Greater adherence to the Nordic diet was also associated with a lower risk of mobility limitations and improved ability to carry out self-care tasks (one study) and a borderline non-significant difference in Activities of Daily Living (one study). A meta-analysis was not performed due to heterogenous outcomes. Although all studies were of good quality, the results should be carefully interpreted due to methodological limitations.
    CONCLUSIONS: Adherence to the Nordic diet could be promising in reducing frailty risk, but more robust studies with equal gender representation and frailty-specific outcomes are needed.
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  • 文章类型: Systematic Review
    北欧国家(丹麦,芬兰,冰岛,挪威,和瑞典)有效地保持了比许多国家更低的抗生素抗性细菌(ARB)病原体率。然而,这些国家正在努力应对ARB病例的增加以及由于ARB病原体的流行而在治疗感染方面面临的挑战.废水监测(WBS)是ARB监测临床方法的宝贵补充,但北欧国家对WBS申请ARB缺乏全面的了解。这篇综述旨在汇编北欧国家用于ARB监测的WBS的最新发展,并将其与临床监测实践进行比较。在审查了初级搜索的1480篇论文后,54人被发现相关,另外还包括15篇与WBS相关的论文。在分析的69项研究中,42专门的临床流行病学,而27人专注于废水监测。PRISMA对文献的回顾表明,北欧国家专注于AMR的四个主要WBS目标:评估人口中的AMR,识别AMR逃避废水处理,量化去除率,并评估潜在的AMR演变。在临床和废水环境中,研究最多的目标是产生碳青霉烯酶和超广谱β-内酰胺酶(ESBL)的病原体,主要是大肠杆菌和克雷伯菌属。然而,耐万古霉素肠球菌(VRE)和耐甲氧西林金黄色葡萄球菌(MRSA)在临床流行病学中受到了比废水研究更多的关注,可能是由于它们在废水中的检出率较低。临床监测主要使用培养,抗生素药敏试验,和基因分型,但是WBS采用了基于PCR和宏基因组学以及基于培养的技术。国际旅行和国外住院导致的进口病例似乎经常导致这些国家ARB病原体病例的增加。北欧国家之间的许多相似之处(例如,知识交流实践,抗生素的使用模式,和当前的ARB景观)可以促进在人口水平筛查中制定和实施ARBWBS的合作努力。
    The Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have effectively kept lower antibiotic-resistant bacterial (ARB) pathogen rates than many other countries. However, in recent years, these five countries have encountered a rise in ARB cases and challenges in treating infections due to the growing prevalence of ARB pathogens. Wastewater-based surveillance (WBS) is a valuable supplement to clinical methods for ARB surveillance, but there is a lack of comprehensive understanding of WBS application for ARB in the Nordic countries. This review aims to compile the latest state-of-the-art developments in WBS for ARB monitoring in the Nordic countries and compare them with clinical surveillance practices. After reviewing 1480 papers from the primary search, 54 were found relevant, and 15 additional WBS-related papers were included. Among 69 studies analyzed, 42 dedicated clinical epidemiology, while 27 focused on wastewater monitoring. The PRISMA review of the literature revealed that Nordic countries focus on four major WBS objectives of ARB: assessing ARB in the human population, identifying ARB evading wastewater treatment, quantifying removal rates, and evaluating potential ARB evolution during the treatment process. In both clinical and wastewater contexts, the most studied targets were pathogens producing carbapenemase and extended-spectrum beta-lactamase (ESBL), primarily Escherichia coli and Klebsiella spp. However, vancomycin-resistant Enterococcus (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) have received more attention in clinical epidemiology than in wastewater studies, probably due to their lower detection rates in wastewater. Clinical surveillance has mostly used culturing, antibiotic susceptibility testing, and genotyping, but WBS employed PCR-based and metagenomics alongside culture-based techniques. Imported cases resulting from international travel and hospitalization abroad appear to have frequently contributed to the rise in ARB pathogen cases in these countries. The many similarities between the Nordic countries (e.g., knowledge exchange practices, antibiotic usage patterns, and the current ARB landscape) could facilitate collaborative efforts in developing and implementing WBS for ARB in population-level screening.
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  • 文章类型: Systematic Review
    本系统评价(a)确定了在北欧国家建立的出生队列研究(BCS),(b)描述其基本特征,(C)探讨这些特征是如何随着时间的推移而演变的,讨论它们对知识生产的影响。为了识别北欧BCS,我们对队列数据库和相关科学文章进行了系统搜索和筛选.审查显示,自1959年以来,超过60万名指数儿童参加了79个北欧BCS(22个丹麦,20芬兰语,12挪威人,24瑞典语,一个冰岛语),其中一半以上仍在进行中。北欧BCS覆盖广泛的地理区域,包括北欧北极。BCS的主题随着时间的推移而变化,但大多数都集中在检查疾病的发育起源上。其中四分之一有一般范围,而其余的从一个特定的焦点开始,常见的特应性疾病。所有BCS都收集了问卷和/或访谈数据,超过60%的BCS宣布了参与者的排除标准,通常语言能力不足。NBCS已经产生了重要的科学知识超过六十年,但是有一些未被充分利用的机会,包括系统的跨学科合作,纳入儿童自己对健康和福祉的看法,代际数据收集,以及北极土著人民和其他少数民族的具体知识。
    This systematic review (a) identifies birth cohort studies (BCSs) established in the Nordic countries, (b) describes their basic characteristics, and (c) explores how these characteristics have evolved over time, discussing their implications to knowledge production. To identify Nordic BCSs, cohort databases and relevant scientific articles were systematically searched and screened.The review shows that since 1959, more than 600,000 index children have participated in the 79 Nordic BCSs (22 Danish, 20 Finnish, 12 Norwegian, 24 Swedish, one Icelandic), over half of them still ongoing. The Nordic BCSs cover a wide geographical area including the Nordic Arctic. The topics of BCSs have varied over time but most have focused on examining the developmental origins of diseases. A quarter of them had a general scope, while the rest started with a specific focus, commonly atopic diseases. All BCSs collected questionnaire and/or interview data and over 60% of the BCSs announced exclusion criteria for participants, typically insufficient language proficiency.NBCSs have produced crucial scientific knowledge for over six decades, but there are underutilised opportunities including systematic interdisciplinary collaboration, inclusion of children\'s own views of their health and well-being, intergenerational data collection, and specific knowledge of Arctic indigenous peoples and other minorities.
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  • 文章类型: Journal Article
    目的:本范围审查的目的是绘制和总结任何北欧国家试图预防出生至7岁儿童肥胖的临床试验。
    方法:PubMed,对CINAHLPlus和clinicaltrials.gov进行了搜索,以获取以英语或瑞典语发表的同行评审论文和注册试验。整个搜索期为2002年1月1日至2022年12月13日。我们纳入了丹麦从出生到7岁的随机和非随机试验,旨在预防肥胖。芬兰,冰岛,挪威和瑞典。
    结果:检索结果为414篇论文和14篇论文。尽管有不同的设置和设计,他们都没有报告人体测量结果一致有利的结果,除了基线时体重指数高的亚组的有益趋势。大多数研究报告称膳食模式暂时改善。
    结论:目前关于如何最好地预防儿童肥胖的研究存在差距。我们建议研究人员应该关注风险人群,并且需要持续数年的干预措施。
    The aim of this scoping review was to map and summarise clinical trials that attempted to prevent obesity in children from birth to 7 years of age in any of the Nordic countries.
    PubMed, CINAHL Plus and clinicaltrials.gov were searched for peer-reviewed papers and registered trials published in English or Swedish. The overall search period was from 1 January 2002 to 13 December 2022. We included randomised and non-randomised trials initiated from birth to 7 years of age that aimed to prevent obesity in Denmark, Finland, Iceland, Norway and Sweden.
    The search resulted in 414 papers and 14 were included. Despite having diverse settings and designs, none of them reported consistently favourable results for anthropometric outcomes, apart from beneficial trends in subgroups with a high body mass index at baseline. Most studies reported temporarily improved dietary patterns.
    There is a gap in the current research about how to best prevent obesity in children. We suggest that researchers should focus on risk groups and that interventions that last a number of years are needed.
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  • 文章类型: Systematic Review
    学生在临床实践中学习的复杂性要求关于如何创建最佳学习能力的全面教学框架。
    这项研究的目的是描述有关调查研究问题的进行研究的特征,不同医疗保健学生群体的分布,并采用了方法论方法。
    选择范围审查以捕捉临床实践中学习领域的多方面特征。对资助的当地项目进行了分析,为文献检索提供了重要的核心概念。根据PRISMA-ScR(23)对北欧国家2000-2019年发表的文章进行了系统的搜索和审查。搜索是在Medline(OVID)进行的,SveMed+和CINAHL,共发表3126篇文章。筛选标题和摘要后,纳入了988篇文章以供进一步审查。根据既定的纳入和排除标准对所有这些文章的摘要进行了审查,并纳入了391篇文章。使用定性内容方法分析了目的和研究问题的特征,从而确定了包括重要类别在内的主题领域。还确定了医疗保健学生群体和方法方法。
    主要研究对象是临床实践组织,监督,和学生的经验,其次是跨专业学习和学习环境。合作,大学临床环境,和患者的角色在小范围内进行了调查。很少出现的主题也是特定的学习成果和基于证据的知识。护理专业的学生参与了74%的研究,20%的医学生,其他职业约占8%。定性方法是最常见的。
    卫生保健学生在临床实践中的学习在北欧国家和重要的学科领域得到了很大程度的研究。该研究显示出提取和描述因素的巨大潜力,以创建具有重要意义的教学框架,以支持学生的学习。
    UNASSIGNED: The complex nature of student learning in clinical practice calls for a comprehensive pedagogical framework on how to create optimal learning affordances.
    UNASSIGNED: The purpose of this study was to describe characteristics of conducted research regarding investigated research questions, distribution of different health care student groups, and employed methodological approaches.
    UNASSIGNED: A scoping review was chosen to capture the multifaceted characteristics in the field of learning in clinical practice. Funded local projects were analysed to provide significant core concepts for the literature search. A systematic search and review of articles published 2000-2019 in the Nordic countries was conducted according to PRISMA- ScR (23). The search was made in Medline (OVID), SveMed+ and CINAHL and resulted in 3126 articles. After screening of the titles and abstracts 988 articles were included for further review. The abstracts of all these articles were reviewed against established inclusion and exclusion criteria and 391 articles were included. Characteristics of purposes and research questions were analysed with a qualitative content approach resulting in identified subject areas including significant categories. Health care student groups and methodological approaches were also identified.
    UNASSIGNED: Subjects predominating the research were organisation of clinical practice, supervision, and students\' experience followed by interprofessional learning and learning environment. Co-operation, university-clinical setting, and patients\' role were investigated to a small extent. Sparsely occurring subjects were also specific learning outcomes and evidence-based knowledge. Nursing students were involved in 74% of the studies, medical students in 20%, and other professions around 8%. Qualitative approaches were most common.
    UNASSIGNED: Health care students\' learning in clinical practice has been researched to a large extent within the Nordic countries and important subject areas are well represented. The research displays a great potential to extract and describe factors to create a pedagogical framework with significant meaning to support students\' learning.
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  • 文章类型: Meta-Analysis
    关于在常规设置中给出的临床代表性治疗存在知识差距,那就是照常治疗(TAU),对于有常见心理健康问题(CMHP)的患者。这篇综述和荟萃分析旨在研究北欧常规诊所中临床代表性疗法的特征,并对此类治疗的结果进行荟萃分析。数据库(PubMed,EMBASE,心理信息,和SveMed+)搜索TAU,CMHP,和北欧国家,以及Scopus的前后搜索(2022年11月7日)。研究要么是随机对照试验(RCT),要么是开放试验,使用前瞻性研究设计,在常规治疗中检查异质门诊组。具有组内和组间效应大小(ES),使用随机效应模型,并计算了主持人分析。11项研究(n=1,413),表现出轻度至中度的组内ES,具有高度异质性(g=0.49,I2=90%)。随机对照试验中的ESs明显小于开放试验中的ESs。与广泛的临床干预相比,TAU的ES略小(g=-0.21;针对发表偏倚进行调整g=-0.06)。与其他干预措施相比,北欧国家的临床代表性疗法表现出多种特征,并且ES也略低。ESs小于其他荟萃分析,检查常规治疗中的循证治疗。
    There is a knowledge gap regarding clinically representative therapy given in routine settings, that is treatment as usual (TAU), for patients with common mental health problems (CMHP). This review and meta-analysis aimed to investigate what characterizes clinically representative therapy in Nordic routine clinics and meta-analyze the outcome of such treatment. Databases (PubMed, EMBASE, PsychINFO, and SveMed+) were searched for TAU, CMHP, and Nordic countries, together with backward and forward search in Scopus (7 November 2022). Studies were either randomized controlled trials (RCT) or open trials, using prospective study designs, examining heterogeneous outpatient groups in routine treatment. Within- and between-group effect sizes (ES), using random effects model, and moderator analyses were calculated. Eleven studies (n = 1,413), demonstrated a small to moderate within-group ES with high heterogeneity (g = 0.49, I2  = 90%). ESs in RCTs were significantly smaller than in open trials. TAU had a marginally smaller ES (g = -0.21; adjusted for publication bias g = -0.06) compared to a broad set of clinical interventions. Clinically representative therapy in the Nordic countries demonstrated a wide variety of characteristics and also a marginally lower ES compared to other interventions. The ESs were smaller than other meta-analyses examining evidence-based treatments in routine treatment.
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