继发性血小板增多症(ST),也称为反应性血小板增多症,是由引发正常血小板形成细胞产生增加的疾病引起的,其特征是骨髓中血小板和巨核细胞数量异常增加。以前的报道发现了恶性肿瘤的并发症,慢性炎症,急性炎症,急性出血,脾切除术,等。是ST的常见原因。然而,由抗生素引起的继发性血小板增多的报道有限,没有以急性心肌梗死为首发表现的继发性血小板增多的报道.如果患者有血栓形成的高风险,需要强化抗血栓治疗.提高临床医师对药物性继发性血小板增多的认识,加强对高危患者的抗栓治疗,本文介绍一例以急性ST段抬高型心肌梗死为主要表现的药物性继发性血小板增多症。
■一名80岁女性因活动后胸痛导致心源性休克。她开始服用阿司匹林和氯吡格雷抗血小板治疗,然后用吲哚布洛芬代替阿司匹林,副作用相对较少。治疗期间血小板计数无显著下降。
■继发性血小板增多症,以非特异性症状为特征,很难诊断。以急性心肌梗死为首发症状的继发性血小板增多症并不常见,但是非常紧急,并且预后不良。更重要的是,病因特异性治疗对继发性血小板增多症的作用.因此,寻找继发性血小板增多的致病因素很重要。由头孢菌素引起的继发性血小板增多很少见。有必要引起临床医生对头孢菌素引起的ST的关注,并为这些患者提供治疗指导。
■经过对相关文献的全面分析,我们发现,几项回顾性研究证明了细胞减灭术治疗显著降低血小板计数的有效性.基于这一发现,我们给病人开了羟基脲,导致血小板计数逐渐减少,并最终恢复到正常水平。
Secondary thrombocythemia (ST), also called reactive thrombocytosis, is caused by a disorder that triggers increased production by normal platelet-forming cells and is characterized by the abnormally increased number of platelet and megakaryocytes in the bone marrow. Previous
reports have found complications from malignant tumors, chronic inflammation, acute inflammation, acute hemorrhage, splenectomy, etc. to be the common causes of ST. However,
reports of secondary thrombocytosis caused by antibiotics are limited and there are no
reports of secondary thrombocytosis with acute myocardial infarction as the first presentation. If the patient is at high risk of thrombosis, intensive antithrombotic therapy is required. To raise clinicians\' awareness of drug-induced secondary thrombocytosis and to enhance antithrombotic therapy for high-risk patients, this article presented a
case of drug-induced secondary thrombocytosis with acute ST-segment elevation myocardial infarction as the primary manifestation.
UNASSIGNED: An 80-year-old woman was admitted with cardiogenic shock due to post-activity chest pain. She was started on aspirin and clopidogrel antiplatelet therapy, then replaced aspirin with indolibuprofen, which has relatively few side effects. There was no significant decrease in platelet counts during treatment.
UNASSIGNED: Secondary thrombocythemia, characterized by nonspecific symptoms, is difficult to diagnose. Secondary thrombocytosis with acute myocardial infarction as the first symptom is uncommon, but is very urgent and associated with a poor prognosis. What\'s more, cause-specific treatment counts for secondary thrombocythemia. Therefore it is important to search for the causal factor of secondary thrombocytosis. Secondary thrombocytosis caused by cephalosporins is rare. There is a need to arouse the attention of clinicians to the ST caused by cephalosporins and to provide a guide of treatment to these patients.
UNASSIGNED: After a thorough analysis of the pertinent literature, we discovered that several retrospective studies demonstrated the effectiveness of cytoreductive therapy in significantly reducing platelet counts. Based on this finding, we prescribed hydroxyurea to our patient, which led to a gradual decrease in platelet count and ultimately resulted in a return to normal levels.