背景:地黄(Gaertn。)DC。(RG)是一种广泛使用的草药,用于清除热量和冷却血液。地黄多糖(Gaertn。)DC。(RGP)具有多种生物活性,包括抗氧化,低血糖,免疫增强,促进造血,和抗焦虑。
目的:这篇综述提供了有关提取和分离方法的最新和全面的信息,结构特征,和RGPs的药理活性。对RGP的结构和临床药理学进行了更深入的研究。为进一步探讨RGPS的药理作用,为临床安全应用和扩大应用范围奠定基础。
方法:使用谷歌学者,Scifinder,PubMed,Springer,Elsevier,威利,WebofScience和其他在线数据库搜索,以收集提取的文献,分离,2022年12月之前发布的RGP的结构分析和药理活性。关键词是\"提取\",\"隔离\",“纯化”和“药理作用”和“地黄多糖”。
结果:地黄自古以来被广泛用于治疗糖尿病,被称为治疗糖尿病的“四圣药”之一,还有人参,番石榴和葛根。在治疗糖尿病方面研究较多的地黄有效成分是地黄多糖和地黄寡糖。多糖的含量因提取方法不同而不同,和分离纯化方法。RGPs具有广泛的药理活性,包括抗肿瘤,免疫调节,神经保护作用,低血糖活动,心脏保护和抗氧化活性。这些药理特性为肿瘤的治疗奠定了基础,炎症,高血糖症,心肌缺血,氧化应激和其他疾病与RGPs。
结论:基于其促进造血的作用,抗肿瘤和增强免疫力,RGPs已在临床上用于治疗慢性再生障碍性贫血和食管癌,但RGPs的其他影响尚未在临床实践中反映出来.在未来,可以对分子结构分析进行更深入的研究,毒性,为进一步探讨RGPs的药理作用,为临床安全应用和扩大应用范围奠定基础。
BACKGROUND: Rehmannia glutinosa (Gaertn.) DC. (RG) is a widely used herb for clearing heat and cooling the blood. Polysaccharides from Rehmannia glutinosa (Gaertn.) DC. (RGPs) have a variety of biological activities, including antioxidation, hypoglycemia, immune enhancement, hematopoiesis promotion, and antianxiety.
OBJECTIVE: This
review provides up-to-date and comprehensive information on the extraction and separation methods, structural characteristics, and pharmacological activities of RGPs. A more in-depth study on the structure and clinical pharmacology of the RGPs was investigated. To further explore the pharmacological effects of RGPS, and lay a foundation for the safe clinical application and expansion of application scope.
METHODS: Use Google Scholar, Scifinder, PubMed, Springer, Elsevier, Wiley, Web of Science and other online database search to collect the literature on extraction, separation, structural analysis and pharmacological activity of RGPs published before December 2022. The key words are \"extraction\", \"isolation\", \"purification\" and \"pharmacological action\" and \"Rehmanniae polysaccharide\".
RESULTS: Rehmannia glutinosa has been widely used in the treatment of diabetes since ancient times, and is known as one of the \"Four Sacred Medicines\" for the treatment of diabetes, along with Ginseng, Psidium Guajava and Pueraria Mirifica. The active ingredients of Rehmannia glutinosa that have been studied more in the treatment of diabetes are Rehmannia glutinosa polysaccharide and Rehmannia glutinosa oligosaccharide. The content of polysaccharides varies due to different extraction methods, and separation and purification methods. RGPs have a wide range of pharmacological activities, including antitumor, immunomodulatory, neuroprotective effect, hypoglycemic activity, cardioprotective and antioxidant activities. These pharmacological properties lay a foundation for the treatment of tumors, inflammation, hyperglycemia, myocardial ischemia, oxidative stress and other diseases with RGPs.
CONCLUSIONS: Based on its effects of promoting hematopoiesis, antitumor and enhancing immunity, RGPs have been clinically applied in the treatment of chronic aplastic anemia and esophageal cancer, but other effects of RGPs have not been reflected in the clinical practice. In the future, more in-depth research can be conducted on the molecular structure analysis, toxicity, side effects and clinical pharmacological effects of RGPs to further explore the pharmacological effects of RGPs and to lay the foundation for safe clinical application and expansion of application scope.