最近的研究报道,HOXB-AS3(HOXB簇反义RNA3)是一种有趣的分子,具有长链非编码RNA(lncRNA)和推定的编码肽在肿瘤发生和发展中的双重功能。HOXB-AS3的显著表达改变在多种癌症类型中被检测到,并且与临床分期和患者生存密切相关。此外,HOXB-AS3参与了一系列实体瘤和血液恶性肿瘤的生物学过程,比如干性,脂质代谢,迁移,入侵,和肿瘤生长。这篇综述全面分析了其对人类肿瘤诊断和预后的临床相关性,并总结了其在不同恶性肿瘤中的功能作用和调节机制。包括肝癌,急性髓系白血病,卵巢癌,肺癌,子宫内膜癌,结肠癌,和口腔鳞状细胞癌。总的来说,HOXB-AS3在多种人类肿瘤中成为有前途的生物标志物和新型治疗靶标。
Recent studies have reported that HOXB-AS3 (HOXB Cluster Antisense RNA 3) is an intriguing molecule with dual functionality as a long noncoding RNA (lncRNA) and putative coding peptide in tumorigenesis and progression. The significant expression alterations of HOXB-AS3 were detected in diverse cancer types and closely correlated with clinical stage and patient survival. Furthermore, HOXB-AS3 was involved in a spectrum of biological processes in solid tumors and hematological malignancies, such as stemness, lipid metabolism, migration, invasion, and tumor growth. This
review comprehensively analyzes its clinical relevance for diagnosis and prognosis across human tumors and summarizes its functional role and regulatory mechanisms in different malignant tumors, including liver cancer, acute myeloid leukemia, ovarian cancer, lung cancer, endometrial carcinoma, colon cancer, and oral squamous cell carcinoma. Overall, HOXB-AS3 emerges as a promising biomarker and novel therapeutic target in multiple human tumors.