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Abstract：
Head and neck squamous cell carcinoma (HNSCC), a common malignancy of the head and neck, is associated with a rapid progression, a high mortality rate and unsatisfactory curative effects. The treatment efficacy is unsatisfactory due to chemotherapeutic drug resistance, the lack of ideal therapeutic agents, as well as the absence of clinical prognostic models. Thus, the identification of novel potential therapeutic targets for its diagnosis and treatment is vital. Ferroptosis is an iron‑dependent regulatory cell death mode different from traditional cell death modes, such as apoptosis and autophagy, and has notable therapeutic potential in cancer treatment. The study of ferroptosis in HNSCC is expected to solve this bottleneck problem. In the present review, the findings, characteristics and regulatory mechanisms of ferroptosis are summarized, with emphasis on the factors and drugs that regulate ferroptosis in HNSCC, in order to provide theoretical basis for the targeted therapy of ferroptosis in HNSCC.
摘要：
头颈部鳞状细胞癌（HNSCC），头颈部常见的恶性肿瘤，与快速发展有关，死亡率高，疗效不理想。由于化疗药物的耐药性，治疗效果不理想，缺乏理想的治疗药物，以及缺乏临床预后模型。因此，识别新的潜在治疗靶点对其诊断和治疗至关重要。Ferroptosis是一种铁依赖性调节性细胞死亡模式，不同于传统的细胞死亡模式。如细胞凋亡和自噬，在癌症治疗中具有显著的治疗潜力。HNSCC中铁凋亡的研究有望解决这一瓶颈问题。在本次审查中，调查结果,综述了铁死亡的特点和调控机制,重点是调节HNSCC铁性凋亡的因素和药物，以期为HNSCC铁性凋亡的靶向治疗提供理论依据。
