PDF(Pubmed)
Abstract：
Tight junctions (TJs) are an important component of cell connectivity; they maintain cell polarity, permeability and adhesion, and participate in the regulation of cell proliferation and differentiation. The claudin (CLDN) family is integral to TJs, and CLDN6 is an important member of this family. Abnormal expression of CLDN6 can destroy the integrity of TJs through various mechanisms and can serve multiple roles in the occurrence and development of tumours. CLDN6 is widely expressed in various tumours but rarely expressed in healthy adult tissues. The aim of this review is to critically examine the recent literature on CLDN6, including its structure, expression in different tumours, regulatory mechanisms and therapeutic prospects. Although some conclusions are controversial, in certain tumours, such as liver, ovarian, endometrial and oesophageal cancer, and atypical teratoid/rhabdoid tumours, research consistently shows that CLDN6 is expressed in tumour tissues but is not expressed or is expressed at low levels in surrounding tissues. In these tumours, CLDN6 has potential as a carcinoembryonic antigen and a therapeutic target.
摘要：
紧密连接（TJ）是细胞连通性的重要组成部分；它们保持细胞极性，渗透性和附着力，参与细胞增殖和分化的调控。Claudin（CLDN）家族是TJ不可或缺的，CLDN6是这个家族的重要成员。CLDN6的异常表达可以通过多种机制破坏TJ的完整性，并在肿瘤的发生和发展中起多种作用。CLDN6在各种肿瘤中广泛表达,但在健康成人组织中很少表达。这篇综述的目的是批判性地审查最近关于CLDN6的文献，包括其结构，在不同肿瘤中的表达，调节机制和治疗前景。虽然有些结论是有争议的，在某些肿瘤中，比如肝脏，卵巢,子宫内膜癌和食道癌，非典型畸胎瘤/横纹肌样瘤,研究一致表明CLDN6在肿瘤组织中表达,但在周围组织中不表达或低水平表达。在这些肿瘤中，CLDN6具有作为癌胚抗原和治疗靶标的潜力。
