背景:由于不健康和现代的生活方式,感染重大疾病的机会增加。菊素是许多植物中黄酮类的类黄酮,包括西番莲和天花.白菊素长期以来一直被用来治疗各种疾病。Chyrin,一种必需的类黄酮,有许多药理作用,包括抗癌,抗病毒,抗炎,抗关节炎,抑郁,降血脂,保肝,和肾保护活性。
目的:这项探索性综述旨在对黄酮类化合物进行全面综述,证实白菊素对肝脏和肾脏具有治疗潜力,并可降低多种毒物引起的肝毒性和肾毒性。这对毒理学家来说是有帮助的,药理学家,和化学家开发新的更安全的药品与chrysin和其他有毒物质。
方法:选择了解释清楚且最符合所选主题的相关研究。对获得的信息进行分析,以通过标题筛选来源来确定结果,abstract,和整个工作。在他们之间,作者决定了要考虑的研究。必要的细节被系统地组织成标题和字幕,并进行了压缩讨论。
方法:本评论中提供的信息是通过在多个在线平台上进行有针对性的搜索获得的,包括谷歌学者,Scifinder,PubMed,科学直接,ACS出版物,Wiley在线图书馆作品是根据所有作者商定的纳入标准选择的。
结果:菊素是一种有前途的生物活性类黄酮,具有显著的健康益处,它的合成替代品正被用作治疗各种疾病的药物。研究结果表明,菊素对几种肝毒性物质如2,3,7,8四氯二苯并对二恶英具有保肝作用,四氯化碳(CCl4),顺铂,和其他人通过降低肝脏毒性生物标志物的水平和提高抗氧化剂水平。此外,chrysin对各种肾毒性物质具有潜在的肾保护特性,比如顺铂,阿霉素,扑热息痛,庆大霉素,链霉素,和其他通过降低肾脏毒性标志物水平,减少氧化应激,并提高抗氧化剂水平。
结论:根据这项修订的研究,chrysin是一种有前途的植物成分,可用作引起肝毒性和肾毒性的各种药物的替代治疗。有了活跃的chrysin,可以配制针对肝脏和肾脏的几种剂型。
BACKGROUND: The chance of contracting significant diseases increases due to an unhealthy and contemporary lifestyle. Chrysin is a flavonoid of the flavone class in numerous plants, including Passiflora and Pelargonium. Chrysin has long been used to treat a variety of illnesses. Chrysin, an essential flavonoid, has many pharmacological actions, including anticancer, antiviral, anti-inflammatory, anti-arthritic, depressive, hypolipidemic, hepatoprotective, and nephroprotective activity.
OBJECTIVE: This explorative
review was commenced to provide a holistic
review of flavonoids confirming that Chrysin has a therapeutic potential on the liver and kidney and reduces the hepatotoxicity and nephrotoxicity induced by diverse toxicants, which can be helpful for the toxicologists, pharmacologists, and chemists to develop new safer pharmaceutical products with chrysin and other toxicants.
METHODS: The most relevant studies that were well-explained and fit the chosen topic best were picked. The achieved information was analyzed to determine the outcome by screening sources by title, abstract, and whole work. Between themselves, the writers decided on the studies to be considered. The necessary details were systematically organized into titles and subtitles and compressively discussed.
METHODS: The information presented in this
review is obtained using targeted searches on several online platforms, including Google Scholar, Scifinder, PubMed, Science Direct, ACS publications, and Wiley Online Library. The works were chosen based on the inclusion criteria agreed upon by all authors.
RESULTS: Chrysin is a promising bioactive flavonoid with significant health benefits, and its synthetic replacements are being utilized as pharmaceuticals to treat various diseases. Findings revealed that Chrysin exhibits hepatoprotective actions against several hepatotoxicants like 2,3,7,8 tetrachlorodibenzo- p-dioxin, carbon tetrachloride (CCl4), cisplatin, and others by lowering the levels of liver toxicity biomarkers and enhancing antioxidant levels. Additionally, chrysin has potential nephroprotective properties against various nephrotoxicants, like Cisplatin, Doxorubicin, Paracetamol, Gentamicin, Streptazosin, and others by dropping kidney toxicity marker levels, reducing oxidative stress, and improving the antioxidant level.
CONCLUSIONS: According to this revised study, chrysin is a promising phytoconstituent that can be utilized as an alternate treatment for various medications that cause hepatotoxicity and nephrotoxicity. With active chrysin, several dosage forms targeting the liver and kidneys can be formulated.