神经系统疾病是多种多样的,有复杂的原因,并经常导致残疾;然而,有效的治疗仍然稀缺。白藜芦醇衍生物蝶芪具有许多生理活性,有望成为中枢神经系统(CNS)疾病的新疗法。本文旨在总结蝶芪在中枢神经系统疾病的体内外模型中的保护机制以及药代动力学和安全性,以评估其对中枢神经系统疾病的可能影响。现有证据支持蝶芪在中枢神经系统疾病中的保护作用,涉及抗氧化和抗炎活性等机制,调节脂质代谢和血管平滑肌细胞增殖,突触功能和神经发生的改善,神经胶质瘤细胞周期阻滞的诱导,并抑制胶质瘤细胞的迁移和侵袭。研究已经确定了可能的分子靶标和途径的保护作用的蝶芪在中枢神经系统疾病,包括AMPK/STAT3,Akt,NF-κB,MAPK,和ERK信号通路。本综述严格讨论了蝶芪在中枢神经系统疾病中可能的药理作用和分子途径。未来的研究应旨在增加我们在动物模型和人类中对蝶芪的理解,以进一步评估其在中枢神经系统疾病中的作用和详细机制。
Neurological disorders are diverse, have complex causes, and often result in disability; yet, effective treatments remain scarce. The resveratrol derivative
pterostilbene possesses numerous physiological activities that hold promise as a novel therapy for the central nervous system (CNS) disorders. This
review aimed to summarize the protective mechanisms of
pterostilbene in in vitro and in vivo models of CNS disorders and the pharmacokinetics and safety to assess its possible effects on CNS disorders. Available evidence supports the protective effects of
pterostilbene in CNS disorders involving mechanisms such as antioxidant and anti-inflammatory activity, regulation of lipid metabolism and vascular smooth muscle cell proliferation, improvement of synaptic function and neurogenesis, induction of glioma cell cycle arrest, and inhibition of glioma cell migration and invasion. Studies have identified possible molecular targets and pathways for the protective actions of pterostilbene in CNS disorders including the AMPK/STAT3, Akt, NF-κB, MAPK, and ERK signaling pathways. The possible pharmacological effects and molecular pathways of pterostilbene in CNS disorders are critically discussed in this
review. Future studies should aim to increase our understanding of
pterostilbene in animal models and humans to further evaluate its role in CNS disorders and the detailed mechanisms.