阿尔茨海默病(Alzheimer’sdisease,AD)是一种复杂的神经系统疾病,可导致认知功能下降和记忆力减退。胆固醇代谢失调已成为AD发病机制中的关键因素。有助于淀粉样β(Aβ)斑块和tau缠结的形成,这种疾病的标志性神经病理学特征。因此,靶向胆固醇代谢作为一种潜在的治疗阿尔茨海默病的方法而受到关注。植物药,它们是从植物和草药中产生的,已显示出有望成为阿尔茨海默病的一种可实现的治疗选择。这些药物含有生物活性化合物,如植物化学物质,黄酮类化合物,和多酚,已证明在调节胆固醇代谢和相关途径方面具有潜力。这篇全面的综述探讨了植物疗法在AD中对胆固醇代谢的调节。它深入研究了胆固醇在大脑功能中的作用,突出显示在AD中观察到的中断。此外,它研究了AD中胆固醇相关病理的潜在分子机制。该综述强调了植物疗法作为AD潜在治疗干预措施的重要性。它讨论了当前治疗方法的缺点以及对解决胆固醇失调及其后果的替代策略的需求。通过对特定植物疗法的深入分析,该审查提供了令人信服的证据,证明了它们的潜在益处。研究了植物治疗对胆固醇代谢影响的分子机制,包括胆固醇相关途径的调节,与Aβ病理学的相互作用,对tau病理学的影响,和抗炎作用。审查还强调了挑战和未来前景,强调标准化,临床证据,和个性化医疗方法,以最大限度地提高AD治疗的治疗潜力。总的来说,植物疗法有望成为AD管理的潜在途径,但是需要进一步的研究和合作来充分探索它们的功效,安全,和行动机制。
Alzheimer\'s disease (AD) is a complex neurological ailment that causes cognitive decline and memory loss. Cholesterol metabolism dysregulation has emerged as a crucial element in AD pathogenesis, contributing to the formation of amyloid-beta (Aβ) plaques and tau tangles, the disease\'s hallmark neuropathological characteristics. Thus, targeting cholesterol metabolism has gained attention as a potential therapeutic method for Alzheimer\'s disease. Phytoremedies, which are generated from plants and herbs, have shown promise as an attainable therapeutic option for Alzheimer\'s disease. These remedies contain bioactive compounds like phytochemicals, flavonoids, and polyphenols, which have demonstrated potential in modulating cholesterol metabolism and related pathways. This comprehensive
review explores the modulation of cholesterol metabolism by phytoremedies in AD. It delves into the role of cholesterol in brain function, highlighting disruptions observed in AD. Additionally, it examines the underlying molecular mechanisms of cholesterol-related pathology in AD. The
review emphasizes the significance of phytoremedies as a potential therapeutic intervention for AD. It discusses the drawbacks of current treatments and the need for alternative strategies addressing cholesterol dysregulation and its consequences. Through an in-depth analysis of specific phytoremedies, the
review presents compelling evidence of their potential benefits. Molecular mechanisms underlying phytoremedy effects on cholesterol metabolism are examined, including regulation of cholesterol-related pathways, interactions with Aβ pathology, influence on tau pathology, and anti-inflammatory effects. The
review also highlights challenges and future perspectives, emphasizing standardization, clinical evidence, and personalized medicine approaches to maximize therapeutic potential in AD treatment. Overall, phytoremedies offer promise as a potential avenue for AD management, but further research and collaboration are necessary to fully explore their efficacy, safety, and mechanisms of action.