前列腺间质瘤,包括前列腺肉瘤和恶性潜能不确定的间质瘤(STUMP),代表了一种非常罕见的前列腺疾病,患病率低于1%。我们提出了一个罕见的病例,涉及一名40多岁的男子被诊断患有STUMP。尽管存在正常的前列腺特异性抗原(PSA)浓度,患者持续排尿困难和肉眼血尿>7个月,导致良性前列腺增生的初步误诊。持续的症状促使进一步调查,磁共振成像(MRI)显示前列腺左侧有可疑病变,最初被认为是恶性的。经直肠前列腺活检证实存在粘液性脂肪肉瘤,没有糖尿病病史,冠心病,或高血压。治疗方法包括机器人辅助腹腔镜前列腺癌根治术,最终导致术后病理明确诊断为STUMP。该病例强调了早期MRI在诊断过程中不可或缺的作用,强调详细的病理检查的必要性,以确定诊断。我们的报告旨在阐明STUMP的诊断挑战和潜在的治疗途径,强调其在前列腺肿瘤的鉴别诊断中的考虑,以提高这种罕见但重要的疾病的临床结果。
Prostatic stromal tumors, encompassing prostatic sarcoma and stromal tumors of uncertain malignant potential (STUMP), represent an exceedingly rare category of prostatic diseases, with a prevalence of less than 1%. We present a rare
case involving a man in his early 40s diagnosed with STUMP. Despite presenting with normal
prostate-specific antigen (PSA) concentrations, the patient experienced persistent dysuria and gross hematuria for >7 months, leading to an initial misdiagnosis of benign prostatic hyperplasia. Persistent symptoms prompted further investigation, with magnetic resonance imaging (MRI) revealing a suspicious lesion on the left side of the
prostate, initially thought to be malignant. Transrectal prostatic biopsy subsequently confirmed the presence of mucinous liposarcoma, with no medical history of diabetes, coronary heart disease, or hypertension. The treatment approach comprised robot-assisted laparoscopic radical prostatectomy, culminating in a postoperative pathological definitive diagnosis of STUMP. This
case underscores the indispensable role of early MRI in the diagnostic process, highlighting the necessity of detailed pathological examination for a conclusive diagnosis. Our report aims to illuminate the diagnostic challenges and potential treatment pathways for STUMP, emphasizing its consideration in the differential diagnosis of prostatic tumors to advance clinical outcomes in this rare but important condition.