■在妊娠合并母亲肥胖和糖尿病的情况下,炎症介质发生破坏,导致内皮微血管功能障碍,氧化应激,组织损伤,以及产妇和胎儿并发症。为了概述这种促炎状态,一种创新的方法是测量促炎细胞因子。在这些生物标志物中,B细胞活化因子(BAFF)和血小板活化因子(PAF)在代谢调节中起关键作用,对感染的免疫反应,组织稳态,和食物相关的炎症。“本研究的目的是调查一组受肥胖和糖尿病影响的孕妇与健康孕妇对照组的血液中BAFF和PAF的表达。
一项前瞻性纵向队列研究已对罗马FondazionePoliclinico大学GemelliIRCCS的孕妇进行。对于每个孕妇来说,在妊娠三个月进行的三个不同的连续评估中,用拭子收集毛细血管样本。
■共有77名孕妇被登记。两组之间纵向观察到BAFF和PAF水平没有显着差异。专注于被曝光的群体,在怀孕的第三个三个月,PAF和BAFF水平均低于基础时间。在选定的一组发生妊娠糖尿病的患者中,与其他组相比,只有PAF值纵向较低.多因素分析显示BAFF水平与促甲状腺激素水平呈正相关。没有巨大儿,没有肩难产,出生时没有严重的会阴撕裂,在整个人群中没有观察到宫内生长受限。
■这项研究支持代谢和促炎生物标志物参与与妊娠并发症相关的机制。改善肥胖和糖尿病孕妇的良好代谢环境可以打破连接炎症的恶性循环,氧化应激,和代谢紊乱。
UNASSIGNED: In pregnancies complicated by maternal obesity and diabetes, a disruption in inflammatory mediators occurs, resulting in endothelial microvascular dysfunction, oxidative stress, tissue damage, and maternal and feto-neonatal complications. To outline this proinflammatory status, an innovative approach is represented by the measurement of proinflammatory cytokines. Among these biomarkers, B-cell-activating factor (BAFF) and platelet-activating factor (PAF) play a key role in metabolic regulation, immune response to infections, tissue homeostasis, and \"food-related inflammation.\" The aim of the present
study is to investigate the blood expression of BAFF and PAF in a cohort of pregnant women affected by obesity and diabetes compared with a control group of healthy pregnant women.
UNASSIGNED: A prospective longitudinal cohort
study has been conducted on pregnant women referred to Fondazione Policlinico Universitario Gemelli IRCCS in Rome. For each pregnant woman, a capillary sample was collected with a swab in three different consecutive evaluations carried out in the three trimesters of pregnancy.
UNASSIGNED: A total of 77 pregnant women have been enrolled. No significant differences in BAFF and PAF levels were longitudinally observed between groups. Focusing on the exposed group, in the third trimester of pregnancy, both PAF and BAFF levels were lower than the basal time. Among the selected group of patients who developed Gestational Diabetes, only PAF values were longitudinally lower when compared to other groups. The multivariate analysis showed that BAFF levels were positively correlated with thyroid-stimulating hormone levels. No macrosomia, no shoulder dystocia, no major perineal lacerations at birth, and no intrauterine growth restriction were observed in the whole population.
UNASSIGNED: This
study supports the involvement of metabolic and proinflammatory biomarkers in the mechanisms related to pregnancy complications. Improving a good metabolic environment for obese and diabetic pregnant women could break the vicious cycle connecting inflammation, oxidative stress, and metabolic disorders.