■中性粒细胞与淋巴细胞比率(NLR)被认为是早期乳腺癌的潜在预后指标。然而,转移性乳腺癌(MBC)的绝对淋巴细胞计数(ALC)和NLR的预后已在一些研究中报道,结论仍然相互矛盾。本手稿旨在为MBC患者中ALC和NLR的预后价值提供进一步的确凿证据。
■通过检索相关电子数据库纳入报告ALC或NLR与MBC之间关联的合格研究。使用总生存期(OS)和无进展生存期(PFS)作为结局指标。收集结果测量的风险比(HR)值和95%置信区间(CI)作为效应大小,并根据汇总的人力资源进行了进一步的分析和讨论,亚组分析,出版偏见,和研究异质性。
■纳入了29项研究,包括3,973例MBC患者。根据我们的发现,较低的ALC与OS(HR=0.57,95%CI0.48至0.68)和PFS(HR=0.68,95%CI0.58至0.79)预后较差显著相关,和较高的NLR与较差的OS(HR=1.50,95%CI1.35至1.67)和PFS(HR=1.82,95%CI1.42至2.35)相关。此外,在关于截止值和种族的亚组分析中,也观察到MBC中ALC和NLR的预后价值.
■观察到低ALC和高NLR与MBC的不良OS和PFS显著相关,表明ALC和NLR可能是MBC患者的潜在预后生物标志物。同时,我们的研究结果也将为MBC患者临床治疗策略的选择和制定提供一些新的证据和研究线索.
■https://www.crd.约克。AC.英国/PROSPERO/,标识符CRD42021224114。
UNASSIGNED: Neutrophil-to-lymphocyte ratio (NLR) is considered a potential prognostic marker in early breast cancer. However, the prognosis of absolute lymphocyte count (ALC) and NLR in metastatic breast cancer (MBC) has been reported in a few studies, and conclusions are still conflicting. This present manuscript aims to provide further solid evidence regarding the prognostic values of ALC and NLR in MBC patients.
UNASSIGNED: Eligible studies that reported the associations between ALC or NLR and MBC were included by searching relative electronic databases. Overall survival (OS) and progression-free survival (PFS) were used as outcome measures. The hazard ratio (HR) values and 95% confidence interval (CI) of the outcome measures were collected as effect sizes, and further analysis and discussion were conducted according to the pooled HR, subgroup analysis, publication bias, and interstudy heterogeneity.
UNASSIGNED: Twenty-nine studies comprising 3,973 patients with MBC were included. According to our findings, lower ALC was significantly associated with poorer prognosis of OS (HR = 0.57, 95% CI 0.48 to 0.68) and PFS (HR = 0.68, 95% CI 0.58 to 0.79), and greater NLR was associated with poorer OS (HR = 1.50, 95% CI 1.35 to 1.67) and PFS (HR = 1.82, 95% CI 1.42 to 2.35). Furthermore, the prognostic values of ALC and NLR in MBC were also observed in the subgroup analyses regarding cutoff values and ethnicities.
UNASSIGNED: Low ALC and elevated NLR were observed to be significantly associated with adverse OS and PFS in MBC, indicating that ALC and NLR may act as potential prognostic biomarkers of MBC patients. Meanwhile, our results will also provide some novel evidence and research clues for the selection and development of clinical treatment strategies for MBC patients.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42021224114.