PDF(Pubmed)
Abstract：
Organophosphorus poisoning (OPP) poses a significant threat to human health, necessitating accurate prognostic markers for timely intervention and improved outcomes. This review evaluates the potential of the neutrophil-to-lymphocyte ratio (NLR) as a prognostic indicator in acute organophosphorus poisoning (AOPP). A comprehensive analysis of existing literature reveals that elevated NLR values correlate with increased severity of poisoning and adverse clinical outcomes, including mortality and morbidity. NLR assessment offers valuable prognostic information beyond traditional markers, aiding risk stratification and guiding clinical decision-making. Integration of NLR into clinical practice holds promise for optimizing patient care through the early identification of high-risk individuals and tailored therapeutic interventions. Further research is needed to validate the utility of NLR in larger patient cohorts and standardize its incorporation into clinical guidelines. Leveraging NLR as a prognostic tool can enhance risk stratification, optimize treatment strategies, and ultimately improve outcomes in AOPP.
摘要：
有机磷中毒对人类健康构成重大威胁,需要准确的预后标志物来及时干预和改善预后。这篇综述评估了中性粒细胞与淋巴细胞比率（NLR）作为急性有机磷中毒（AOPP）预后指标的潜力。对现有文献的综合分析显示，NLR值升高与中毒严重程度增加和不良临床结局相关。包括死亡率和发病率。NLR评估提供了超越传统标志物的有价值的预后信息，辅助风险分层，指导临床决策。将NLR纳入临床实践有望通过早期识别高风险个体和量身定制的治疗干预措施来优化患者护理。需要进一步的研究来验证NLR在较大患者队列中的实用性，并将其标准化纳入临床指南。利用NLR作为预后工具可以增强风险分层，优化治疗策略，并最终改善AOPP的结果。
