Platelet mass index

  • 文章类型: Journal Article
    目的:我们旨在研究急性胆囊炎急诊患者初始血小板指标的变化。
    方法:在三级护理教学医院进行了回顾性病例对照研究。人口统计,合并症,实验室数据,住院时间,急性胆囊炎组的死亡率数据从医院数字数据库中回顾性获得.血小板计数,平均血小板体积,Plateletcrit,血小板分布宽度,收集血小板质量指数。
    结果:共553例急性胆囊炎患者为研究病例,541名医院员工为研究对照。根据所研究血小板指标的多变量分析结果,只有平均血小板体积和血小板分布宽度显示两组之间存在显著差异(调整比值比:2,95%置信区间:1.4-2.7,p<0.001;调整比值比:5.88,95%置信区间:2.44-14.4,p<0.001).建立的多元回归模型在预测急性胆囊炎时的曲线下面积为0.969(准确性:0.917,敏感性:89%,特异性:94.5%)。
    结论:研究结果表明,初始平均血小板体积和血小板分布宽度是急性胆囊炎的独立预测因子。
    OBJECTIVE: We aimed to investigate changes in initial platelet indices in patients arriving at the emergency department with acute cholecystitis.
    METHODS: A retrospective case-control study was conducted at a tertiary care teaching hospital. Demographics, comorbidities, laboratory data, length of hospital stay, and mortality data for the acute cholecystitis group were retrospectively obtained from the hospital digital database. Platelet count, mean platelet volume, plateletcrit, platelet distribution width, and platelet mass index were collected.
    RESULTS: A total of 553 patients with acute cholecystitis were the study cases, and 541 hospital employees were the study controls. According to the results of the multivariate analysis of the platelet indices studied, only mean platelet volume and platelet distribution width showed significant differences between the two groups (adjusted odds ratio: 2, 95% confidence interval: 1.4-2.7, p < 0.001 and adjusted odds ratio: 5.88, 95% confidence interval: 2.44-14.4, p < 0.001, respectively). The multivariate regression model created had an area under the curve of 0.969 in the prediction of acute cholecystitis (accuracy: 0.917, sensitivity: 89%, and specificity: 94.5%).
    CONCLUSIONS: The study results indicate that the initial mean platelet volume and platelet distribution width were independent predictors of acute cholecystitis.
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  • 文章类型: Journal Article
    (1) Background: Retinopathy of prematurity (ROP) can cause severe visual impairment or even blindness. We aimed to assess the hematological risk factors that are associated with different stages of ROP in a cohort of preterm newborns, and to compare the clinical characteristics and therapeutic interventions between groups. (2) Methods: This retrospective study included 149 preterm newborns from a tertiary maternity hospital in Romania between January 2018 and December 2018, who were segregated into: Group 1 (with ROP, n = 59 patients), and Group 2 (without ROP, n = 90 patients). The patients that were affected by ROP were subsequently divided into the following subgroups: Subgroup 1 (Stage 1, n = 21), Subgroup 2 (Stage 2, n = 35), and Subgroup 3 (Stage 3, n = 25). The associations were analyzed using multivariate logistic regression and sensitivity analysis. (3) Results: Platelet mass indexes (PMI) that were determined in the first, seventh, and tenth days of life were significantly associated with Stage 1 ROP. PMI determined in the first day of life was also significantly associated with Stage 2 ROP. The sensitivity and specificity of these parameters were modest, ranging from 44 to 57%, and 59 to 63%. (4) Conclusions: PMI has a modest ability to predict the development of ROP.
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  • 文章类型: Journal Article
    BACKGROUND: Atrial fibrillation (AF) is the most common complication after cardiac surgery. The pathogenesis of postoperative atrial fibrillation (POAF) is multifactorial and one of the known factors is inflammation. Platelet mass index (PMI) is an indicator of platelet activation and a better inflammatory marker than mean platelet volume (MPV). In this retrospective study, we investigated the relationship between POAF and PMI.
    METHODS: The study included 848 consecutive patients (655 male and 193 female) who had elective isolated coronary artery by-pass grafting (CABG) or combined CABG and valvular surgery. Platelet count and MPV were measured from preoperative blood samples to calculate PMI. Post-operative atrial fibrillation was defined as irregular and fibrillatory P waves occurring 48-96 h after cardiac surgery and lasting at least 30 s. The PMI values in patients who developed POAF were compared with those in patients who did not develop POAF.
    RESULTS: Patients who developed POAF had higher PMI values (2549.3 ± 1077.1) when compared with patients in sinus rhythm (2248.1 ± 683.4; p < 0.01). In multivariate regression analysis, age (OR: 1.05; 95% CI: 1.02-1.09; p = 0.01), left atrial diameter (OR: 1.05; 95% CI: 1.03-1.09; p = 0.02), hs-CRP (OR: 1.09; 95%CI: 1.05-1.13; p < 0.01), EuroSCORE II (OR: 1.27; 95% CI: 1.14-1.41; p < 0.01), and PMI (OR: 1.01; 95% CI: 1.001-1.02; p < 0.01) were independent predictors of POAF. In ROC analysis, PMI ≥ 2286 predicted POAF development with a sensitivity of 69% and a specificity of 58% (AUC: 0.66; p < 0.01) CONCLUSION: A significant relationship was found between preoperatively calculated PMI and POAF. We showed that PMI may be used to predict patients who are at high risk of developing POAF.
    UNASSIGNED: HINTERGRUND: Vorhofflimmern („atrial fibrillation“, AF) stellt die häufigste Komplikation nach Herzoperationen dar. Die Pathogenese des postoperativen AF (POAF) ist multifaktoriell, und einer der bekannten Faktoren ist die Entzündung. Der Plättchenmassenindex (PMI) dient als Indikator der Plättchenaktivierung und stellt einen besseren Entzündungsmarker als das mittlere Plättchenvolumen (MPV) dar. In der vorliegenden retrospektiven Studie wurde der Zusammenhang zwischen POAF und PMI untersucht.
    METHODS: In die Studie wurden 848 konsekutive Patienten einbezogen (655 Männer und 193 Frauen), bei denen eine elektive isolierte Koronararterienbypassoperation (CABG) oder eine Kombination aus CABG und Klappenchirurgie durchgeführt worden war. Plättchenzahl und MPV wurden anhand von präoperativen Blutproben ermittelt, um dann den PMI zu berechnen. Ein POAF war definiert als irreguläre und fibrillatorische P‑Wellen, die 48–96 h nach der Herzoperation auftraten und mindestens 30 s dauerten. Die PMI-Werte von Patienten, bei denen POAF auftrat, wurden mit den Werten von Patienten verglichen, bei denen kein POAF auftrat.
    UNASSIGNED: Patienten, bei denen POAF auftrat, wiesen höhere PMI-Werte auf (2549,3 ± 1077,1) als Patienten mit einem Sinusrhythmus (2248,1 ± 683,4; p < 0,01). Bei der multivariaten Regressionsanalyse stellten Alter (Odds Ratio, OR: 1,05; 95%-KI: 1,02–1,09; p = 0,01), linker Vorhofdurchmesser (OR: 1,05; 95%-KI: 1,03–1,09; p = 0,02), hochsensitives C‑reaktives Protein (hs-CRP; OR: 1,09; 95%-KI: 1,05–1,13; p < 0,01), EuroSCORE II (OR: 1,27; 95%-KI: 1,14–1,41; p < 0,01) und PMI (OR: 1,01; 95%-KI: 1,001–1,02; p < 0,01) unabhängige Prädiktoren eines POAF dar. In der Receiver-Operating-Characteristic(ROC)-Analyse war ein PMI ≥ 2286 Prädiktor für die Entwicklung eines POAF mit einer Sensitivität von 69% und einer Spezifität von 58% („area under the curve“, AUC: 0,66; p < 0,01).
    UNASSIGNED: Zwischen präoperativ berechnetem PMI und POAF wurde ein signifikanter Zusammenhang festgestellt. Es wurde gezeigt, dass der PMI als Prädiktor für Patienten eingesetzt werden kann, bei denen ein hohes Risiko für das Auftreten eines POAF besteht.
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