Abstract：
OBJECTIVE: We aimed to investigate changes in initial platelet indices in patients arriving at the emergency department with acute cholecystitis.
METHODS: A retrospective case-control study was conducted at a tertiary care teaching hospital. Demographics, comorbidities, laboratory data, length of hospital stay, and mortality data for the acute cholecystitis group were retrospectively obtained from the hospital digital database. Platelet count, mean platelet volume, plateletcrit, platelet distribution width, and platelet mass index were collected.
RESULTS: A total of 553 patients with acute cholecystitis were the study cases, and 541 hospital employees were the study controls. According to the results of the multivariate analysis of the platelet indices studied, only mean platelet volume and platelet distribution width showed significant differences between the two groups (adjusted odds ratio: 2, 95% confidence interval: 1.4-2.7, p < 0.001 and adjusted odds ratio: 5.88, 95% confidence interval: 2.44-14.4, p < 0.001, respectively). The multivariate regression model created had an area under the curve of 0.969 in the prediction of acute cholecystitis (accuracy: 0.917, sensitivity: 89%, and specificity: 94.5%).
CONCLUSIONS: The study results indicate that the initial mean platelet volume and platelet distribution width were independent predictors of acute cholecystitis.
METHODS: A retrospective case-control study was conducted at a tertiary care teaching hospital. Demographics, comorbidities, laboratory data, length of hospital stay, and mortality data for the acute cholecystitis group were retrospectively obtained from the hospital digital database. Platelet count, mean platelet volume, plateletcrit, platelet distribution width, and platelet mass index were collected.
RESULTS: A total of 553 patients with acute cholecystitis were the study cases, and 541 hospital employees were the study controls. According to the results of the multivariate analysis of the platelet indices studied, only mean platelet volume and platelet distribution width showed significant differences between the two groups (adjusted odds ratio: 2, 95% confidence interval: 1.4-2.7, p < 0.001 and adjusted odds ratio: 5.88, 95% confidence interval: 2.44-14.4, p < 0.001, respectively). The multivariate regression model created had an area under the curve of 0.969 in the prediction of acute cholecystitis (accuracy: 0.917, sensitivity: 89%, and specificity: 94.5%).
CONCLUSIONS: The study results indicate that the initial mean platelet volume and platelet distribution width were independent predictors of acute cholecystitis.
摘要：
目的：我们旨在研究急性胆囊炎急诊患者初始血小板指标的变化。
方法：在三级护理教学医院进行了回顾性病例对照研究。人口统计,合并症,实验室数据,住院时间,急性胆囊炎组的死亡率数据从医院数字数据库中回顾性获得.血小板计数,平均血小板体积,Plateletcrit,血小板分布宽度,收集血小板质量指数。
结果：共553例急性胆囊炎患者为研究病例，541名医院员工为研究对照。根据所研究血小板指标的多变量分析结果,只有平均血小板体积和血小板分布宽度显示两组之间存在显著差异(调整比值比:2,95%置信区间:1.4-2.7,p<0.001;调整比值比:5.88,95%置信区间:2.44-14.4,p<0.001).建立的多元回归模型在预测急性胆囊炎时的曲线下面积为0.969（准确性：0.917，敏感性：89％，特异性：94.5%）。
结论：研究结果表明，初始平均血小板体积和血小板分布宽度是急性胆囊炎的独立预测因子。
方法：在三级护理教学医院进行了回顾性病例对照研究。人口统计,合并症,实验室数据,住院时间,急性胆囊炎组的死亡率数据从医院数字数据库中回顾性获得.血小板计数,平均血小板体积,Plateletcrit,血小板分布宽度,收集血小板质量指数。
结果：共553例急性胆囊炎患者为研究病例，541名医院员工为研究对照。根据所研究血小板指标的多变量分析结果,只有平均血小板体积和血小板分布宽度显示两组之间存在显著差异(调整比值比:2,95%置信区间:1.4-2.7,p<0.001;调整比值比:5.88,95%置信区间:2.44-14.4,p<0.001).建立的多元回归模型在预测急性胆囊炎时的曲线下面积为0.969（准确性：0.917，敏感性：89％，特异性：94.5%）。
结论：研究结果表明，初始平均血小板体积和血小板分布宽度是急性胆囊炎的独立预测因子。
