目的：评估早产儿出生后第一天血液学参数与支气管肺发育不良（BPD）之间的关系。
方法：这项回顾性研究涉及2017年1月至2022年6月入住我们新生儿重症监护病房的所有早产儿。根据缺氧暴露≥28天诊断BPD。中性粒细胞与淋巴细胞比率（NLR），血小板与淋巴细胞比率（PLR），血小板计数(PLT),平均血小板体积（MPV），比较有和没有BPD的婴儿的血小板质量指数（PMI）。进行多因素分析以评估血液学参数与BPD之间的关联。
结果：这项研究涉及124名早产儿（48名患有BPD，76没有BPD）。BPD组具有较低的胎龄和较低的体重。NLR,MPV,BPD组PLR明显高于非BPD组,PLT和MPI明显低于非BPD组。在调整协变量后，Logistic回归分析表明，NLR，PLT,PMI和PMI是BPD的独立危险因素。此外，接收机工作特性曲线表明，NLR，PLT,PMI和PMI是BPD的可靠预测因子。
结论：我们的研究结果表明，第一天较高的NLR和较低的PLT和PMI可能会增加BPD的风险。
OBJECTIVE: To evaluate the association between hematological parameters on the first day of life and bronchopulmonary dysplasia (BPD) in preterm infants.
METHODS: This retrospective study involved all premature infants admitted to our neonatal intensive care unit from January 2017 to June 2022. BPD was diagnosed based on hypoxia exposure for ≥28 days. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet count (PLT), mean platelet volume (MPV), and platelet mass index (PMI) were compared between infants with and without BPD. Multivariate analysis was conducted to evaluate the association between hematological parameters and BPD.
RESULTS: This study involved 124 premature infants (48 with BPD, 76 without BPD). The BPD group had a lower gestational age and lower weight. The NLR, MPV, and PLR were considerably higher and the PLT and MPI were lower in the BPD than non-BPD group. After adjusting for covariates, logistic regression analysis suggested that the NLR, PLT, and PMI were independent risk factors for BPD. Moreover, the receiver operating characteristic curve indicated that the NLR, PLT, and PMI were reliable predictors of BPD.
CONCLUSIONS: Our findings suggest that a higher NLR and a lower PLT and PMI on the first day may increase the risk of BPD.
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