背景:本研究提供了口腔黑棘皮瘤的病例系列和范围审查,以检查其临床,组织病理学,和免疫组织化学特征。
方法:病例系列包括9例口腔黑棘皮瘤。从活检图收集临床数据。进行苏木精-伊红和TRP2,CD3和CD20的免疫组织化学。对于范围审查,MEDLINE/PubMed,WebofScience,EMBASE,Scopus被搜查了.
结果:病例系列:平均年龄为46.8岁(男女比例2:1)。病灶平均大小为11.0mm(±9.3)。病变主要为黄斑(77.8%),呈棕色或黑色(88.9%),常累及多个部位(44.4%)。进化时间为15天至96个月。病变常表现为上皮性棘皮病(66.7%),海绵体(55.6%),胞吐作用(77.8%),黑色素失禁(88.9%),固有层的炎症浸润(77.8%),都显示了淋巴细胞。TRP2阳性黑素细胞在所有病例的基底和棘层均有鉴定,在三个病例的表层。CD3阳性细胞优于CD20阳性细胞。范围回顾:从55项研究中检索到85例口腔黑棘皮瘤。患者主要为女性(男女比例2.2:1),黑皮肤(64.1%),平均年龄36.13(±17.24)。病变平坦(81.9%),通常为棕色(62.4%)。颊粘膜是首选部位(32.9%),其次是多个网站(28.2%)。
结论:口腔黑棘皮瘤主要影响广泛年龄范围的女性,病变通常表现为棕色/黑色斑疹,特别是在颊粘膜上。一直发现TRP2阳性黑素细胞和T淋巴细胞,并可能参与口服黑色素瘤的发病机理。
BACKGROUND: This study presents a
case series and scoping review of oral melanoacanthoma to examine its clinical, histopathological, and immunohistochemical characteristics.
METHODS: Nine cases of oral melanoacanthoma were included in the
case series. Clinical data were collected from biopsy charts. Hematoxylin-eosin and immunohistochemistry for TRP2, CD3, and CD20 were done. For the scoping review, MEDLINE/PubMed, Web of Science, EMBASE, and Scopus were searched.
RESULTS: Case series: The mean age was 46.8 years (female-to-male ratio 2:1). Lesion\'s mean size was 11.0 mm (±9.3). Lesions were mainly macular (77.8%) with brown or black coloration (88.9%) and often affected multiple sites (44.4%). The evolution time ranged from 15 days to 96 months. Lesions commonly showed epithelial acanthosis (66.7%), spongiosis (55.6%), exocytosis (77.8%), melanin incontinence (88.9%), and inflammatory infiltrate in the lamina propria (77.8%), from which all showed lymphocytes. TRP2-positive melanocytes were identified in the basal and spinous layer of all cases, and in the superficial layer of three cases. CD3-positive cells predominate over the CD20-positive. Scoping review: 85 cases of oral melanoacanthoma were retrieved from 55 studies. Patients were primarily female (female-to-male ratio 2.2:1), black-skinned (64.1%), with a mean age of 36.13 (± 17.24). Lesions were flat (81.9%), often brown (62.4%). Buccal mucosa was the preferred site (32.9%), followed by multiple sites (28.2%).
CONCLUSIONS: Oral melanoacanthoma mainly affects women across a wide age range, with lesions commonly appearing as brown/black macules, particularly on the buccal mucosa. TRP2-positive melanocytes and T-lymphocytes were consistently found and could participate in oral melanoacanthoma pathogenesis.