背景:近年来,癌症患者的生存率显着提高。然而,这也导致了副作用的增加,如呼吸困难,这会对患者产生负面影响。我们提出了一项再教育工作方案。主要目的是测试该计划在改善癌症患者呼吸道症状和功能方面的有效性。
方法:实验,prospective,纵向,采用并行固定分配方案(CG-IG)的随机研究。患者从萨拉曼卡大学医院综合医院(CAUSA)的肿瘤内科服务中选择,西班牙。为两个研究组设计了两个平行的干预计划(常规临床实践-努力再教育计划)。主要变量:呼吸困难(MRC),功能(Barthel);次要变量:身体表现(SPPB)和功能能力(ECOG)以及社会人口统计学变量(年龄,性别,解剖病理学诊断,和治疗线的数量)。
结果:研究样本包括182名患者,排除12个,最终样本量为n=170。性别分布(CG:男性52.9%,女性47.1%;IG:男性49.4%,女性50.6%)。主要的肿瘤诊断是肺癌,最常见的肿瘤分期是III期和IV期。在IG和CG评分之间(p<0.001,d=0.887,95%CI)以及IG和CG评分之间(p=0.004,d=0.358,95%CI)之间存在统计学上的显着差异,这表明IG的表现更好。
结论:这项研究的结果支持运动再教育计划的有益效果,由跨学科团队开展,以提高肿瘤患者呼吸困难的自主性。
背景:该临床试验已在ClinicalTrials.gov(NCT04186754)中注册。(2019年9月3日)。
BACKGROUND: In recent years, there has been a significant increase in the survival rates of cancer patients. However, this has also led to an increase in side effects, such as dyspnoea, which can negatively impact of patients. We propose a programme for re-educating effort. The main objective is to test the effectiveness of this programme in improving respiratory symptoms and functionality in cancer patients.
METHODS: Experimental, prospective, longitudinal, randomised
study with a parallel fixed-assignment scheme (CG-IG). The patients were selected from the Medical Oncology Service of the University Hospital Complex of Salamanca (CAUSA), Spain. Two parallel intervention programmes were designed for the two
study groups (Conventional Clinical Practice-Effort Re-education Programme). Primary variables: dyspnoea (MRC), functionality (Barthel); secondary variables: physical performance (SPPB) and functional capacity (ECOG) and the socio-demographic variables (age, sex, anatomopathological diagnosis, and number of treatment lines).
RESULTS: The
study sample consisted of 182 patients, with 12 excluded, resulting in a final sample size of n = 170. Sex distribution (CG: 52.9% male and 47.1% female; IG: 49.4% male and 50.6% female). The primary oncological diagnosis was lung cancer, and the most frequent tumour stages were III and IV. Statistically significant differences were found between the IG and CG scores (p < 0.001, d = 0.887, 95% CI) and between the IG and CG scores (p = 0.004, d = 0.358, 95% CI), indicating that the IG performed better.
CONCLUSIONS: The results of this
study support the beneficial effects of an exercise re-education programme, carried out by an interdisciplinary team in improving the autonomy of oncology patients with dyspnoea.
BACKGROUND: The clinical
trial was registered in ClinicalTrials.gov (NCT04186754). (03 September 2019).