PDF(Pubmed)
Abstract：
UNASSIGNED: Physical performance tests are predictive of mortality and may screen for certain health conditions (e.g., sarcopenia); however, their diagnostic and/or prognostic value has primarily been studied in age-limited or disease-specific cohorts. Our objective was to identify the most salient characteristics associated with three lower quarter balance and strength tests in a cohort of community-dwelling adults.
UNASSIGNED: We applied a stacked elastic net approach on detailed data on sociodemographic, health and health-related behaviors, and biomarker data from the first visit of the Project Baseline Health Study (N = 2,502) to determine which variables were most associated with three physical performance measures: single-legged balance test (SLBT), sitting-rising test (SRT), and 30-second chair-stand test (30CST). Analyses were stratified by age (<65 and ≥65).
UNASSIGNED: Female sex, Black or African American race, lower educational attainment, and health conditions such as non-alcoholic fatty liver disease and cardiovascular conditions (e.g., hypertension) were consistently associated with worse performance across all three tests. Several other health conditions were associated with either better or worse test performance, depending on age group and test. C-reactive protein was the only laboratory value associated with performance across age and test groups with some consistency.
UNASSIGNED: Our results highlighted previously identified and several novel salient factors associated with performance on the SLBT, SRT, and 30CST. These tests could represent affordable, noninvasive biomarkers of prevalent and/or future disease in adult individuals; future research should validate these findings.
UNASSIGNED: ClinicalTrials.gov, identifier NCT03154346, registered on May 15, 2017.
UNASSIGNED: We applied a stacked elastic net approach on detailed data on sociodemographic, health and health-related behaviors, and biomarker data from the first visit of the Project Baseline Health Study (N = 2,502) to determine which variables were most associated with three physical performance measures: single-legged balance test (SLBT), sitting-rising test (SRT), and 30-second chair-stand test (30CST). Analyses were stratified by age (<65 and ≥65).
UNASSIGNED: Female sex, Black or African American race, lower educational attainment, and health conditions such as non-alcoholic fatty liver disease and cardiovascular conditions (e.g., hypertension) were consistently associated with worse performance across all three tests. Several other health conditions were associated with either better or worse test performance, depending on age group and test. C-reactive protein was the only laboratory value associated with performance across age and test groups with some consistency.
UNASSIGNED: Our results highlighted previously identified and several novel salient factors associated with performance on the SLBT, SRT, and 30CST. These tests could represent affordable, noninvasive biomarkers of prevalent and/or future disease in adult individuals; future research should validate these findings.
UNASSIGNED: ClinicalTrials.gov, identifier NCT03154346, registered on May 15, 2017.
摘要：
■身体机能测试可以预测死亡率，并可以筛查某些健康状况(例如，肌少症)；然而，其诊断和/或预后价值主要在年龄限制或疾病特异性队列中进行研究.我们的目标是在社区居住的成年人队列中确定与三个下四分之一平衡和力量测试相关的最突出特征。
■我们对社会人口统计学的详细数据应用了堆叠弹性网方法，健康和健康相关行为，和来自项目基线健康研究首次访问的生物标志物数据（N=2,502），以确定哪些变量与三个身体表现指标最相关：单腿平衡测试（SLBT），坐立试验(SRT),和30秒椅架测试（30CST）。分析按年龄（<65和≥65）分层。
■女性,黑人或非裔美国人种族，受教育程度较低，和健康状况，如非酒精性脂肪肝疾病和心血管疾病(例如，在所有三个测试中，高血压）始终与较差的表现相关。其他几种健康状况与更好或更差的测试性能有关，取决于年龄组和测试。C反应蛋白是唯一与年龄和测试组表现相关的实验室值，具有一定的一致性。
■我们的结果强调了先前确定的以及与SLBT性能相关的几个新的突出因素，SRT,30CST这些测试可能是负担得起的，成人个体中流行和/或未来疾病的非侵入性生物标志物;未来的研究应该验证这些发现.
■ClinicalTrials.gov,标识符NCT03154346，注册于2017年5月15日。
■我们对社会人口统计学的详细数据应用了堆叠弹性网方法，健康和健康相关行为，和来自项目基线健康研究首次访问的生物标志物数据（N=2,502），以确定哪些变量与三个身体表现指标最相关：单腿平衡测试（SLBT），坐立试验(SRT),和30秒椅架测试（30CST）。分析按年龄（<65和≥65）分层。
■女性,黑人或非裔美国人种族，受教育程度较低，和健康状况，如非酒精性脂肪肝疾病和心血管疾病(例如，在所有三个测试中，高血压）始终与较差的表现相关。其他几种健康状况与更好或更差的测试性能有关，取决于年龄组和测试。C反应蛋白是唯一与年龄和测试组表现相关的实验室值，具有一定的一致性。
■我们的结果强调了先前确定的以及与SLBT性能相关的几个新的突出因素，SRT,30CST这些测试可能是负担得起的，成人个体中流行和/或未来疾病的非侵入性生物标志物;未来的研究应该验证这些发现.
■ClinicalTrials.gov,标识符NCT03154346，注册于2017年5月15日。
