PDF(Pubmed)
Abstract：
Tests of physical function are often thought to measure functioning that is (1) musculoskeletal, and (2) newly declining in adult life. In contrast, this study aimed to: (1) add to evidence that physical-function tests also measure brain function, and (2) test the novel hypothesis that adult physical function is associated with brain function beginning in early childhood. We investigated early childhood brain function and midlife physical function in the Dunedin Study, a 5-decade longitudinal birth cohort (n = 1,037).
Brain function was measured at age 3 using 5 measures which formed a reliable composite (neurological examination, cognitive and motor tests, and temperament ratings). Physical function was measured at age 45 using 5 measures which formed a reliable composite (gait speed, step-in-place, chair stands, balance, and grip strength).
Children with worse age-3 brain function had worse midlife physical function as measured by the age-45 composite, even after controlling for childhood socioeconomic status (β: 0.23; 95% CI: 0.16 to 0.30; p < .001). Worse age-3 brain function significantly predicted slower gait speed, fewer steps-in-place and chair-stands, worse balance, and weaker grip strength.
Children with poorer brain function were more likely to have poorer physical-function scores as adults. In addition to indicating recent musculoskeletal decline, physical-function tests may also provide indications of lifelong, integrated brain-body health. By reconceptualizing the meaning of physical-function scores, clinicians can orient the use of physical-function tests in a more holistic approach to health care.
Brain function was measured at age 3 using 5 measures which formed a reliable composite (neurological examination, cognitive and motor tests, and temperament ratings). Physical function was measured at age 45 using 5 measures which formed a reliable composite (gait speed, step-in-place, chair stands, balance, and grip strength).
Children with worse age-3 brain function had worse midlife physical function as measured by the age-45 composite, even after controlling for childhood socioeconomic status (β: 0.23; 95% CI: 0.16 to 0.30; p < .001). Worse age-3 brain function significantly predicted slower gait speed, fewer steps-in-place and chair-stands, worse balance, and weaker grip strength.
Children with poorer brain function were more likely to have poorer physical-function scores as adults. In addition to indicating recent musculoskeletal decline, physical-function tests may also provide indications of lifelong, integrated brain-body health. By reconceptualizing the meaning of physical-function scores, clinicians can orient the use of physical-function tests in a more holistic approach to health care.
摘要：
目的：身体功能测试通常被认为是测量功能，即（1）肌肉骨骼，(2)成人生活新下降。相比之下,这项研究旨在:(1)增加身体功能测试也测量大脑功能的证据，和（2）检验了新的假设，即成人的身体功能与从儿童早期开始的大脑功能有关。我们在达尼丁研究中调查了儿童早期的大脑功能和中年的身体功能，一个50年的纵向出生队列(n=1037)。
方法：在3岁时使用五种方法测量脑功能，这些方法形成了可靠的综合（神经学检查，认知和运动测试，气质评级）。在45岁时使用五种测量方法测量身体功能，这些测量形成了可靠的复合材料(步态速度，步骤到位，椅子的立场，balance,握力)。
结果：以45岁复合指数衡量，3岁大脑功能较差的儿童中年身体功能较差，即使在控制了儿童社会经济地位(β，0.23；95%CI，0.16-0.30；P<.001）。更糟糕的3岁大脑功能显着预测步态速度较慢，更少的台阶和椅子支架，更差的平衡,和较弱的握力。
结论：大脑功能较差的儿童与成年人相比，身体功能评分较差的可能性更大。除了表明最近的肌肉骨骼下降，身体功能测试也可以提供终身的迹象，综合脑体健康。通过重新概念化身体功能评分的含义，临床医生可以在更全面的医疗保健方法中指导身体功能测试的使用。
方法：在3岁时使用五种方法测量脑功能，这些方法形成了可靠的综合（神经学检查，认知和运动测试，气质评级）。在45岁时使用五种测量方法测量身体功能，这些测量形成了可靠的复合材料(步态速度，步骤到位，椅子的立场，balance,握力)。
结果：以45岁复合指数衡量，3岁大脑功能较差的儿童中年身体功能较差，即使在控制了儿童社会经济地位(β，0.23；95%CI，0.16-0.30；P<.001）。更糟糕的3岁大脑功能显着预测步态速度较慢，更少的台阶和椅子支架，更差的平衡,和较弱的握力。
结论：大脑功能较差的儿童与成年人相比，身体功能评分较差的可能性更大。除了表明最近的肌肉骨骼下降，身体功能测试也可以提供终身的迹象，综合脑体健康。通过重新概念化身体功能评分的含义，临床医生可以在更全面的医疗保健方法中指导身体功能测试的使用。
