猫口腔鳞状细胞癌(FOSCC)是猫中最常见的口腔肿瘤。这种恶性肿瘤是局部侵袭性的,死亡率很高,其病因尚不清楚。在人类中,头颈部鳞状细胞癌与烟草烟雾有关,酒精消费,和人乳头瘤病毒感染。在这里,对FOSCC的潜在病因进行了严格审查,考虑2000年至2022年之间的出版物,旨在综合有关此问题的所有可用科学证据。遵循PRISMA声明和Cochrane协作的建议,并使用MeSH术语MeSH术语“口头”搜索PubMed数据库,\"口\",\"语言\",\"唇\",\"gingiva\",“癌”,\"鳞状\",和“猫科动物”。符合条件的研究的选择过程基于特定的纳入和排除标准以及评估的研究质量。最初的搜索结果是553种出版物,只有26项被纳入审查。16项研究与病毒病因有关,9项与环境因素有关,例如暴露于烟草烟雾,外寄生虫产品,以及口腔合并症的存在。评估时,在16.2%的FOSCC样本中检测到猫乳头瘤病毒。在三项关注烟草烟雾暴露的研究中,35.2%(30/85)患有FOSCC的猫有这种暴露史。罐头食品的消费和驱虫项圈的使用是相关的,只有一个出版物,肿瘤形成的风险增加了4.7倍和5.3倍,分别。在485只患有FOSCC的猫中,6.4%有牙齿和口腔病理学(即,牙周病或猫慢性牙龈炎)。本研究表明,FOSCC病因的现有证据仍然有限,然而,人们对这个话题越来越感兴趣。为了更好地了解这种侵袭性疾病的可能病因的作用,并为其人类对应的模型,大,需要前瞻性的多机构研究。
Feline oral squamous cell carcinoma (FOSCC) is the most common oral neoplasia in cats. This malignant tumor is locally invasive, has a high mortality rate, and its etiology is not yet known. In humans, head and neck squamous cell carcinoma is associated with tobacco smoke, alcohol consumption, and human
papillomavirus infection. Herein, a critical
review about the potential etiologic factors of FOSCC was performed, considering publications between 2000 and 2022, aiming to synthesize all available scientific evidence regarding this issue. Recommendations of the PRISMA statement and the Cochrane Collaboration were followed and the PubMed database searched by using the MeSH terms MeSH terms \"oral\", \"mouth\", \"lingual\", \"labial\", \"gingiva\", \"carcinoma\", \"squamous\", and \"feline\". The selection process for eligible studies was based on specific inclusion and exclusion criteria and the quality of the studies assessed. The initial search resulted in 553 publications, with only 26 of these being included in the
review. Sixteen studies were related to viral etiology and nine related to environmental factors such as exposure to tobacco smoke, ectoparasitic products, and the presence of oral comorbidities. When evaluated, feline
papillomavirus was detected in 16.2% of samples of FOSCC. In the three studies focused on exposure to tobacco smoke, 35.2% (30/85) of cats with FOSCC had a history of this exposure. The consumption of canned food and the use of deworming collars were associated, in only one publication, with a risk of neoplasia increased by 4.7 and 5.3 times, respectively. Among 485 cats with FOSCC, 6.4% had dental and oral pathology (i.e., periodontal disease or feline chronic gingivostomatitis). The present study demonstrates that the available evidence on the etiology of FOSCC is still limited, however, there has been an increasing interest on this topic. To better understand the role of the possible etiological factors of this aggressive disease, and model for its human counterpart, large, prospective multi-institutional studies are needed.