Abstract：
To summarize the distribution of types of human papillomavirus (HPV) associated with HPV-related diseases and investigate the potential causes of high prevalence of HPV 52 and 58 by summarizing the prevalence of lineages, sub-lineages, and mutations among Chinese women. We searched PubMed, EMBASE, CNKI, and WanFang from January, 2012 to June, 2023 to identify all the eligible studies. We excluded patients who had received HPV vaccinations. Data were summarized in tables and cloud/rain maps. A total of 102 studies reporting HPV distribution and 15 studies reporting HPV52/HPV58 variants were extracted. Among Chinese women, the top five prevalent HPV types associated with cervical cancer (CC) were HPV16, 18, 58, 52, and 33. In patients with vaginal cancers and precancerous lesions, the most common HPV types were 16 and 52 followed by 58. For women with condyloma acuminatum (CA), the most common HPV types were 11 and 6. In Chinese women with HPV infection, lineage B was the most prominently identified for HPV52, and lineage A was the most common for HPV58. In addition to HPV types 16, which is prevalent worldwide, our findings revealed the unique high prevalence of HPV 52/58 among Chinese women with HPV-related diseases. HPV 52 variants were predominantly biased toward lineage B and sub-lineage B2, and HPV 58 variants were strongly biased toward lineage A and sub-lineage A1. Further investigations on the association between the high prevalent lineage and sub-lineage in HPV 52/58 and the risk of cancer risk are needed. Our findings underscore the importance of vaccination with the nine-valent HPV vaccine in China.
摘要：
目的总结人乳头瘤病毒(HPV)与HPV相关疾病的类型分布,并通过总结谱系的流行情况,探讨HPV52和58高流行的潜在原因。次谱系，和中国女性的变异。我们搜索了PubMed,EMBASE,CNKI,和万方从一月开始，2012年6月,2023年确定所有符合条件的研究。我们排除了接受HPV疫苗接种的患者。数据汇总在表格和云/雨地图中。共提取102项报告HPV分布的研究和15项报告HPV52/HPV58变体的研究。在中国女性中,与宫颈癌(CC)相关的前5种流行HPV类型为HPV16,18,58,52和33.在患有阴道癌和癌前病变的患者中，最常见的HPV类型为16和52,其次为58.对于患有尖锐湿疣（CA）的女性，最常见的HPV类型是11和6.在中国患有HPV感染的女性中，谱系B在HPV52中最突出，谱系A在HPV58中最常见。除了全球流行的HPV16型，我们的研究结果揭示了在患有HPV相关疾病的中国女性中HPV52/58的独特高患病率.HPV52变体主要偏向于谱系B和亚谱系B2,并且HPV58变体强烈偏向于谱系A和亚谱系A1。需要进一步研究HPV52/58中的高流行谱系和亚谱系与癌症风险之间的关联。我们的发现强调了在中国接种九价HPV疫苗的重要性。
