背景:神经鞘瘤是一种周围神经鞘源性良性肿瘤。虽然最常见于四肢,头部,和颈部,文献报道了罕见的胰腺内或邻近的神经鞘瘤病例。
方法:我们介绍了一名无症状且健康的57岁男性,在腹部计算机断层扫描(CT)上发现了3.5×3.7cm的胰腺周围肿块。患者在我们医院接受了肿块的完全摘除。切除标本的病理分析显示纺锤形细胞。免疫组织化学染色S100蛋白表达阳性,确认胰腺周围神经鞘瘤的明确诊断。患者术后病程顺利。
结论:神经鞘瘤通常是良性的,封装,以及由周围神经的髓鞘生成细胞引起的缓慢生长的肿瘤。神经鞘瘤表现在实性腹部内脏内或附近,比如胰腺,术前诊断可能具有挑战性,因为它可能模仿其他病变。神经鞘瘤的放射学外观可能是非特异性的,明确的诊断取决于病理分析。使用内窥镜超声(EUS)与细针穿刺(FNA)可以帮助临床医生术前诊断,然而,这些干预措施并不广泛可用。胰周神经鞘瘤的准确术前诊断非常重要,因为它可能会阻止不必要的胰腺切除术或根治性切除术。
结论:虽然罕见,神经鞘瘤应该是胰腺内部或周围的囊性或实性肿块的鉴别诊断的一部分。完全切除预后良好,几乎没有复发。
BACKGROUND: Schwannomas are a benign tumor of peripheral nerve sheath origin. Although most commonly arising in the extremities, head, and neck there have been rare cases of schwannomas presenting within or adjacent to the pancreas reported in the literature.
METHODS: We present an asymptomatic and otherwise healthy 57-year-old male with an incidental peripancreatic mass measuring 3.5 × 3.7 cm found on abdominal computed tomography (CT). The patient underwent complete enucleation of the mass at our hospital. Pathological analysis of the excised specimen showed spindle shaped cells. Immunohistochemical staining was positive for S100 protein expression, confirming the definitive diagnosis of peripancreatic schwannoma. The patient\'s postoperative course was uneventful.
CONCLUSIONS: Schwannoma is a commonly benign, encapsulated, and slowly growing tumor arising from myelin producing cells of peripheral nerves. A schwannoma presenting within or adjacent to solid abdominal viscera, such as the pancreas, may be challenging to diagnose preoperatively as it may mimic other lesions. Radiological appearance of schwannoma may be nonspecific and definitive diagnosis is reliant upon pathological analysis. The use of endoscopic ultrasound (EUS) with fine needle aspiration (FNA) may assist the clinician in preoperative diagnosis, however these interventions are not widely available. Accurate preoperative diagnosis of a peripancreatic schwannoma is of high importance as it may preclude unnecessary pancreatectomy or radical resection.
CONCLUSIONS: Although rare, schwannoma should be part of the differential diagnosis of a cystic or solid appearing mass within or surrounding the pancreas. Total resection carries an excellent prognosis with little to no documented recurrence.