PDF(Pubmed)
Abstract：
Small cell lung cancer (SCLC) is notorious for its aggressive behavior and propensity for metastasis. Although metastasis to the pancreas from SCLC is relatively rare, it warrants attention due to its overlapping symptomatology with primary pancreatic malignancies and other abdominal pathologies (such as those involving the liver or gallbladder). Despite recent advances, the mechanisms driving SCLC metastasis to the pancreas remain elusive, providing challenges in diagnosis and treatment. This case report details the presentation of a 59-year-old woman with SCLC metastasis to the pancreas, initially masquerading as primary pancreatic carcinoma, as highlighted by her presenting symptoms of jaundice, weight loss, and abdominal pain. Diagnostic workup, including imaging studies and tissue sampling, confirmed the unexpected presence of metastatic SCLC in the pancreas. The patient was ultimately transferred to a tertiary care facility for further workup. This case serves as a reminder to maintain a broad differential diagnosis, particularly in the face of such an unusual presentation. It also highlights the need for further research to elucidate the molecular and cellular mechanisms driving SCLC metastasis to the pancreas, with the ultimate goal of improving diagnostic accuracy and therapeutic outcomes for patients with this aggressive disease.
摘要：
小细胞肺癌（SCLC）因其侵袭行为和转移倾向而臭名昭著。虽然从SCLC转移到胰腺是相对罕见的，由于其与原发性胰腺恶性肿瘤和其他腹部病变（例如涉及肝脏或胆囊的病变）的症状重叠，因此值得关注。尽管最近取得了进展，驱动SCLC转移到胰腺的机制仍然难以捉摸，在诊断和治疗方面提出挑战。该病例报告详细介绍了一名59岁女性的胰腺SCLC转移，最初伪装成原发性胰腺癌，正如她表现出黄疸症状所强调的那样，减肥,和腹痛。诊断检查,包括成像研究和组织取样，证实胰腺中意外存在转移性SCLC。患者最终被转移到三级护理机构进行进一步的检查。这种情况提醒人们保持广泛的鉴别诊断，尤其是面对如此不同寻常的表现。它还强调需要进一步研究以阐明驱动SCLC转移到胰腺的分子和细胞机制。最终目标是提高这种侵袭性疾病患者的诊断准确性和治疗结果。
