POSAS

POSAS
  • 文章类型: Journal Article
    本文概述了未来三年在英国多个中心进行的一项研究的协议。这是由美国国家医疗保健研究所(NIHR)资助的患者利益研究(RfPB)研究。目的是评估在瘢痕形成的早期用脉冲染料激光(PDL)治疗肥厚性烧伤瘢痕的有效性。目的是通过改善烧伤疤痕的外观和质量来提高患者的生活质量,以及减少其心理影响。这是一个随机的平行臂,对照试验,比较PDL和标准护理与标准护理。测量基线和6个月随访之间的差异。新兵在烧伤愈合后三个月内;伤口显示出肥厚性疤痕的明确可能性。在多中心研究中招募了总共120名患者;以1:1分配给每个臂的随机化。除标准护理外,治疗组每隔6周接受3次PDL治疗,而控制臂只接受标准护理。主要结果是患者和观察者疤痕量表(POSAS)的患者分级部分。使用CARE烧伤量表评估心理和心理社会影响(UWE,布里斯托尔)和质量调整寿命年(QALY)是使用短期健康调查(SF-12)确定的。该研究通过经济分析评估成本效益,并通过电话访谈评估患者报告的治疗经验。
    This paper outlines the protocol for a study that is being carried out at multiple centres across the UK in the next three years. It is a Research for Patient Benefit (RfPB) study funded by the National Institute for Healthcare Research (NIHR). The aim is to assess the effectiveness of treating hypertrophic burns scars with pulsed dye laser (PDL) at an early stage of scar formation. The objective is to improve Quality of Life for the patient by improving both the appearance and quality of burn scarring, as well as reducing its psychological impact. This is a parallel-arm randomised, controlled trial to compare PDL and standard care against standard care alone. The difference is measured between baseline and six-month follow-up. Recruits are within three months of healing from a burn injury; with wounds showing a defined potential for hypertrophic scarring. A total of 120 patients are recruited in a multi-centre study; with randomisation in a 1:1 allocation to each arm. The treatment arm receives 3 PDL treatments at six-week intervals in addition to standard care, whereas the control arm receives standard care alone. The primary outcome is the patient-rated part of the Patient and Observer Scar Scale (POSAS). Psychological and psycho-social impact is evaluated using the CARe burn scale (UWE, Bristol) and Quality Adjusted Life Years (QALY) is determined using the Short-Form Health Survey (SF-12). The study evaluates both the cost-effectiveness through an economic analysis and the patient-reported experience of the treatment by phone interviews.
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