未经批准:辣木(Bakerf.)库德夫。和MenthaspicataL.被广泛用于治疗糖尿病的传统医学系统,高血压,消化问题和各种疾病。在啮齿动物模型中,M.stenopetala和M.spicata凉茶的叶子配方显示出更好的抗糖尿病和抗高血压作用。然而,其长期安全性尚未得到调查。因此,这项研究调查了Wistar白化病大鼠中M.stenopetala和M.spicata凉茶叶制剂的亚慢性(90天)口服毒性。
UNASSIGNED:将四组大鼠(n=10,5/性别/组)随机分为对照组(媒介物)组和三个实验组(559.36、1118.72和2237.44mg/kg,分别)。三个测试组每天接受M.stenopetala和M.spicata叶混合的凉茶,持续90天。对照组接受蒸馏水。在治疗期间,每天观察临床体征,每周测量大鼠的食物消耗和体重变化。实验结束时,宏观病理学,对血液和生化参数进行了评估。此外,肝脏组织病理学,肾,心,检查胃和胰腺。
未经证实:亚慢性口服M.stenopetala和M.spicata叶混合物的凉茶在治疗组大鼠中没有导致死亡或明显的毒性症状。此外,凉茶对体重没有显著变化,食物摄入量,器官重量,两种性别的血液学和生化参数。然而,血清AST,男女用2237.44mg/kg凉茶处理的大鼠的CK和LDH水平均显着升高。器官的组织学没有明显改变,肝脏只有轻微的病变,观察到肾脏和胰腺。
UNASSIGNED:研究结果表明,在亚慢性暴露中,M.stenopetala和M.spicata叶混合物的凉茶对大鼠相对安全/低毒性。然而,进一步的临床前(慢性,致畸,生殖和发育毒性)需要在动物中进行研究,以便具有足够的安全性和毒性特征用于人类。
UNASSIGNED: Moringa stenopetala (Baker f.) Cudof. and Mentha spicata L. are widely used in the traditional system of medicine for the treatment of diabetes, hypertension, digestive problems and various disorders. The leaves formulation of M. stenopetala and M. spicata herbal tea showed better antidiabetic and antihypertensive effects in rodent models. However, its long-term safety profile has not been investigated yet. Thus, this study investigated the subchronic (90 days) oral toxicity of the leaves formulation of M. stenopetala and M. spicata herbal tea in Wistar albino rats.
UNASSIGNED: Four groups of rats (n = 10, with 5/sex/group) were randomly assigned into a control (vehicle) group and three test groups (559.36, 1118.72 and 2237.44 mg/kg, respectively). The three test groups received the herbal tea of M. stenopetala and M. spicata leaves blend daily for 90 days. The control group received distilled water. During the treatment period, clinical signs were observed daily, and food consumption and body weight changes of the rats were measured weekly. At the end of the experiment, macro-pathological, hematological and biochemical parameters were evaluated. Furthermore, histopathology of liver, kidney, heart, stomach and pancreas were examined.
UNASSIGNED: Subchronic oral administration of the herbal tea of M. stenopetala and M. spicata leaves blend did not result in death or significant toxicity signs in the treated group rats. Moreover, the herbal tea caused no significant changes on body weight, food intake, organ weight, hematological and biochemical parameters in either sex. However, the serum AST, CK and LDH levels were significantly elevated in rats treated with 2237.44 mg/kg of herbal tea in both sexes. There was no significant alteration in the histology of organs, only minor lesions in the liver, kidney and pancreas were observed.
UNASSIGNED: The study results indicate that the herbal tea of M. stenopetala and M. spicata leaves blend is relatively safe/low toxic to rats in subchronic exposure. However, further preclinical (chronic, teratogenic, reproductive and developmental toxicity) studies in animals are required in order to have sufficient safety and toxicity profiles for its use in humans.