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Abstract：
In Southeast Asia, the rhizome of Etlingera pavieana is commonly consumed and parts of the rhizomes have been used as a medicine for the treatment of several disorders. Its pharmacological effects have previously been reported. However, its potential toxicity has not been described. This study aimed to evaluate in vivo toxicity of E. pavieana rhizome extract (EPE) in Sprague Dawley rats. Acute toxicity testing of EPE at a single dose of 2,000 mg/kg produced no toxic effects in female rats after 14 days of treatment. Subchronic toxicity testing showed that all doses of EPE (500, 1,000, and 2,000 mg/kg/day) produced no sign of toxicity during 90 days of treatment. All biochemical and hematological values were within normal ranges. There were no significant histopathological differences in the internal organs among the tested groups. Therefore, the no-observed-adverse-effect level of EPE was 2,000 mg/kg/day in both male and female rats, thereby confirming the safety of EPE for use in traditional medicines.
摘要：
在东南亚,Etlingerapaveiana的根茎通常被食用，根茎的一部分已被用作治疗几种疾病的药物。其药理作用先前已有报道。然而,其潜在毒性尚未描述。本研究旨在评价紫菜根茎提取物(EPE)对SD大鼠的体内毒性。单剂量2,000mg/kg的EPE的急性毒性测试在处理14天后在雌性大鼠中没有产生毒性作用。亚慢性毒性测试表明，所有剂量的EPE（500、1,000和2,000mg/kg/天）在90天的治疗期间均未产生毒性迹象。所有生化和血液学值均在正常范围内。测试组之间的内部器官没有显着的组织病理学差异。因此,在雄性和雌性大鼠中，未观察到的EPE不良反应水平为2,000mg/kg/天，从而确认EPE用于传统药物的安全性。
