UASSIGNED:中风后上肢的运动功能障碍禁止中风患者在日常生活中独立。应用fNIRS探索康复干预下的脑活动是神经康复的研究热点。
未经授权:本研究的目的是探索,使用夹紧释放环电机任务,利用fNIRS技术和测试量表对在亚急性卒中早期接受手矫形器单侧任务导向治疗的卒中患者的感兴趣区域的激活变化和运动功能变化。这项研究旨在首先找到一个敏感的运动任务和感兴趣的区域,然后在下一个随机对照试验中利用fNIRS技术评估这种康复方法的可行性和机制。
UNASSIGNED:在本例系列中,八个右撇子,右侧偏瘫亚急性中风病人(6名男性,招募了2名年龄在47至72岁之间的女性)。他们接受了30分钟的无矫形器单侧任务导向治疗和30分钟的矫形器单侧任务导向治疗(5天/周),为期4周。使用fNIRS估算了使用握力释放环运动任务基于氧合血红蛋白浓度变化的激活通道数和β值。临床结果测量,包括握力评估,动作研究手臂测试,和Fugl-Meyer对手臂的评估,同时进行评估。
未经评估:个体激活分析表明,干预后,受试者1、2、6、7和8的最大平均β值位于左运动前皮层,而受试者4和5的最大平均β值位于左感觉运动皮层。受试者3的激活分析显示最大平均β值位于右前运动皮层。左感觉运动皮层失活,左运动前皮质,干预后观察到与其他病例不同的双侧前额叶皮质。组激活分析显示,所有8名参与者的双侧大脑半球都被激活,右半球和右辅助运动皮层显著激活。干预之后,两侧半球的激活减少,但在不同的脑区;左感觉运动皮质的激活强度有趋势,右运动前皮层,右前额叶皮层降低,左运动前皮层和左前额叶皮层激活强度增加。每位参与者在干预后的所有临床试验量表都表现出改善。
未经授权:左运动前皮层,左感觉运动皮层,右补充运动皮层可能是主要的关注区域。抓握释放环任务不适合实现我们的fNIRS研究目标,应在进一步的研究中使用更灵敏的运动任务或更灵敏的评估指标。
UNASSIGNED: Motor dysfunction in the upper extremities after stroke prohibits people with stroke from being independent in daily living. The application of fNIRS to explore brain activity under rehabilitation intervention is a research focus on neurorehabilitation.
UNASSIGNED: The purpose of this study was to explore, using a grip-release ring motor task, the activated changes of regions of interest and changes in motor function utilizing fNIRS technology and test scales on persons with stroke who received unilateral task-oriented therapy with a hand
orthosis in the early subacute stroke period before and after intervention. The study aimed to find a sensitive motor task and region of interest first, then to evaluate the feasibility and mechanism of this rehabilitation method by utilizing fNIRS technology in the next randomized controlled trial.
UNASSIGNED: In this
case series, eight right-handed, right hemiplegia subacute stroke persons (6 males,2 females from age 47 to 72) were enrolled. They received 30 min of unilateral task-oriented therapy without
orthosis and 30 min of unilateral task-oriented therapy with
orthosis (5 days/week) for 4 weeks. Activated channel numbers and beta values based on oxygenated hemoglobin concentration change using a grip-release ring motor task were estimated with fNIRS. Clinical outcome measures, including grip strength evaluation, action research arm test, and Fugl-Meyer assessment of the arm, were evaluated at the same time.
UNASSIGNED: Individual activation analysis showed that, after intervention, Subjects 1, 2, 6, 7, and 8 had the maximum mean beta value located in the left premotor cortex, while Subjects 4 and 5 had the maximum mean beta value located in the left sensorimotor cortex. The activation analysis of Subject 3 showed the maximum mean beta value located in the right premotor cortex. Deactivations of left sensorimotor cortex, left premotor cortex, and bilateral prefrontal cortex were observed after intervention which were different from other cases. Group activation analysis showed that bilateral cerebral hemispheres were activated in all eight participants, with right hemisphere and right supplementary motor cortex activated dominantly. After the intervention, the activation of bilateral hemispheres decreased but in different brain regions; there was a trend that the activation intensity of left sensorimotor cortex, right premotor cortex, and right prefrontal cortex decreased while activation intensity of left premotor cortex and left prefrontal cortex increased. Each participant demonstrated improvements in all the clinical test scales after intervention.
UNASSIGNED: Left premotor cortex, left sensorimotor cortex, and right supplementary motor cortex may be the primary regions of interest. Grasp-release ring task was not appropriate to achieve our fNIRS research objective and a more sensitive motor task or more sensitive evaluating indicator should be used in further studies.