UNASSIGNED:许多最近的临床研究表明,脑机接口(BCI)的结合可以诱导神经恢复和运动功能的改善。在这次审查中,我们进行了系统综述和荟萃分析,以评估BCI机器人系统的临床效果.
UNASSIGNED:2010年1月至2020年12月发布的文章已通过使用数据库进行了搜索(EMBASE,PubMed,CINAHL,EBSCO,WebofScience和手动搜索)。对单组研究进行了定性描述,荟萃分析仅纳入对照试验研究.合并Fugl-Meyer评估(FMA)评分的平均差异(MD),并使用随机效应模型方法进行荟萃分析。目前的审查遵循了PRISMA标准。
未经评估:总共确定了897条记录,8项单组研究和11项对照试验研究被纳入我们的综述.系统分析表明,BCI机器人系统在运动功能恢复方面有了显着改善。荟萃分析显示,BCI机器人组和机器人组之间没有统计学差异,无论是直接效应还是长期效应(p>0.05)。
UNASSIGNED:BCI机器人系统的使用对偏瘫上肢的运动功能恢复有显着改善,并且有持续的效果。Meta分析显示实验组(BCI-机器人)和对照组(机器人)之间无统计学差异。然而,现有研究的实验设计存在一些不足,需要进行更多的临床试验,实验设计需要更加严格。对康复的影响在这篇综述中,我们评估了脑机接口与机器人对脑卒中后康复上肢功能的临床效果。在我们筛选了数据库之后,这篇综述包括19篇文章。这些文章都是临床试验研究,他们都使用了非侵入性的脑机接口和上肢机器人。我们用九篇文章进行了系统的回顾,结果表明,BCI机器人系统在运动功能恢复方面有显著改善。包括11篇文章进行荟萃分析,结果表明,BCI机器人组和机器人组之间没有统计学差异,无论是直接影响还是长期影响。我们认为没有统计学差异的荟萃分析结果可能是由这些文章的临床试验设计的异质性引起的。我们认为BCI机器人系统是中风后康复的有希望的策略。并对进一步的研究提出了几点建议:(1)实验设计应更加严格,并详细描述实验设计,尤其是对照组干预,使实验具有可复制性。(2)需要建立新的评价标准,更客观的评估,如生物力学评估,fMRI应作为主要结果。(3)更多的临床研究,样本量更大,新颖的外部设备,和BCI系统需要进行调查BCI机器人系统和其他干预措施之间的差异。(4)进一步的研究可以将重点转移到亚急性期的患者,探讨早期BCI训练是否能对大脑皮层恢复产生积极影响。
UNASSIGNED: Many recent clinical studies have suggested that the combination of brain-computer interfaces (BCIs) can induce neurological recovery and improvement in motor function. In this
review, we performed a systematic
review and meta-analysis to evaluate the clinical effects of BCI-robot systems.
UNASSIGNED: The articles published from January 2010 to December 2020 have been searched by using the databases (EMBASE, PubMed, CINAHL, EBSCO, Web of Science and manual search). The single-group studies were qualitatively described, and only the controlled-trial studies were included for the meta-analysis. The mean difference (MD) of Fugl-Meyer Assessment (FMA) scores were pooled and the random-effects model method was used to perform the meta-analysis. The PRISMA criteria were followed in current
review.
UNASSIGNED: A total of 897 records were identified, eight single-group studies and 11 controlled-trial studies were included in our
review. The systematic analysis indicated that the BCI-robot systems had a significant improvement on motor function recovery. The meta-analysis showed there were no statistic differences between BCI-robot groups and robot groups, neither in the immediate effects nor long-term effects (p > 0.05).
UNASSIGNED: The use of BCI-robot systems has significant improvement on the motor function recovery of hemiparetic upper-limb, and there is a sustaining effect. The meta-analysis showed no statistical difference between the experimental group (BCI-robot) and the control group (robot). However, there are a few shortcomings in the experimental design of existing studies, more clinical trials need to be conducted, and the experimental design needs to be more rigorous.Implications for RehabilitationIn this review, we evaluated the clinical effects of brain-computer interface with robot on upper-limb function for post-stroke rehabilitation. After we screened the databases, 19 articles were included in this
review. These articles all clinical trial research, they all used non-invasive brain-computer interfaces and upper-limb robot.We conducted the systematic
review with nine articles, the result indicated that the BCI-robot system had a significant improvement on motor function recovery. Eleven articles were included for the meta-analysis, the result showed there were no statistic differences between BCI-robot groups and robot groups, neither in the immediate effects nor long-term effects.We thought the result of meta-analysis which showed no statistic difference was probably caused by the heterogenicity of clinical trial designs of these articles.We thought the BCI-robot systems are promising strategies for post-stroke rehabilitation. And we gave several suggestions for further research: (1) The experimental design should be more rigorous, and describe the experimental designs in detail, especially the control group intervention, to make the experiment replicability. (2) New evaluation criteria need to be established, more objective assessment such as biomechanical assessment, fMRI should be utilised as the primary outcome. (3) More clinical studies with larger sample size, novel external devices, and BCI systems need to be conducted to investigate the differences between BCI-robot system and other interventions. (4) Further research could shift the focus to the patients who are in subacute stage, to explore if the early BCI training can make a positive impact on cerebral cortical recovery.