背景:在世界卫生组织列出的21种被忽视的热带病(NTD)中,15影响中华人民共和国。尽管在控制NTD方面取得了重大成就,仍然缺乏基于实际病例数据和时空动态的详细信息的疾病负担综合评估。本研究旨在评估2005-2020年中国NTDs的疾病负担和时空分布,为制定符合全球卫生议程的国家卫生议程提供参考。并指导资源分配。
方法:从中国公共卫生科学数据中心下载了2005年至2020年中国主要NTD的病例数和死亡人数(https://www.phsciencedata.cn/股/指数。中国疾病预防控制中心的jsp)和相关文献。残疾调整寿命年(DALYs)的简化公式有助于估计寿命损失年(YLL),残疾生活年(YLDs),和总DALY。使用MoranI统计量对2005年至2020年的平均NTDs负荷数据进行了空间自相关分析。
结果:中国的总体NTDs负担显着下降,从2005年的245,444.53DALYs到2020年的18,984.34DALYs,减少了92.27%。2005年,由血吸虫病和狂犬病引起的DALY占总疾病负担的很大一部分,分别占65.37%和34.43%。2015年,湖南和四川省的NTD多样性最高,分别报道了9个和8个不同的NTD。疾病负担最高的是四川(242,683.46DALYs),西藏紫支曲(178,318.99DALYs)和广东(154,228.31DALYs)。NTD的“高-高”聚集区域主要在中国的中部和南部地区,通过空间自相关分析确定。
结论:中国在防治NTDs方面做出了不懈努力,我国主要NTDs的疾病负担明显下降。运用OneHealth理念指导现场疾病预防控制,有效节约医疗资源,实现精准干预。
BACKGROUND: Out of the 21 neglected tropical diseases (NTDs) listed by the World Health Organization, 15 affect the People\'s Republic of China. Despite significant achievements in controlling NTDs, comprehensive assessments of the disease burden based on actual case data and detailed information on spatial and temporal dynamics are still lacking. This study aims to assess the disease burden and spatial-temporal distribution of NTDs in China from 2005 to 2020, to provide a reference for the formulation of national health agendas in line with the global health agenda, and guide resource allocation.
METHODS: The number of cases and deaths of major NTDs in China from 2005 to 2020 were downloaded from the China Public Health Science Data Center ( https://www.phsciencedata.cn/Share/index.jsp ) of the Chinese Center for Disease Control and Prevention and relevant literatures. Simplified formulas for disability-adjusted life years (DALYs) helped estimate the years of life lost (YLLs), years lived with disability (YLDs), and total DALYs. Spatial autocorrelation analysis of the average NTDs burden data for the years 2005 to 2020 was evaluated using Moran\'s I statistic.
RESULTS: China\'s overall NTDs burden decreased significantly, from 245,444.53 DALYs in 2005 to 18,984.34 DALYs in 2020, marking a reduction of 92.27%. In 2005, the DALYs caused by schistosomiasis and rabies represent a substantial proportion of the total disease burden, accounting for 65.37% and 34.43% respectively. In 2015, Hunan and Sichuan provinces had the highest diversity of NTDs, with 9 and 8 number of different NTDs reported respectively. And the highest disease burden was observed in Sichuan (242,683.46 DALYs), Xizang Zizhiqu (178,318.99 DALYs) and Guangdong (154,228.31 DALYs). The \"high-high\" clustering areas of NTDs were mainly in China\'s central and southern regions, as identified by spatial autocorrelation analysis.
CONCLUSIONS: China has made unremitting efforts in the prevention and control of NTDs, and the disease burden of major NTDs in China has decreased significantly. Using the One Health concept to guide disease prevention and control in the field to effectively save medical resources and achieve precise intervention.