乳腺癌是最常见的癌症,癌症相关死亡的第五大原因,也是全球女性癌症死亡的第二大原因。最近的研究为植物化学物质的重要性提供了越来越多的支持,饮食和非饮食,特别是三萜类化合物,在乳腺癌的缓解和管理中。最近的研究表明,通过对乳腺癌细胞实施几种分子作用模式,三萜类化合物是治疗和抑制乳腺癌的有前途的药物。这篇综述讨论了植物三萜类化合物的最新创新及其在2017年至2023年的时间段内对抗乳腺癌的潜在作用机制。本工作是对不同植物三萜类化合物具有显著抑制增殖的概述。迁移,凋亡抗性,肿瘤血管生成,或在各种乳腺癌细胞中转移。三萜类化合物的抗癌作用可能归因于它们的抗增殖活性干扰血管生成和分化。细胞凋亡的调节,DNA聚合酶抑制,信号转导的变化,并阻碍转移。本审查侧重于几个目标,机制,和与五环三萜类相关的途径,负责它们的抗癌作用。我们可以得出结论,天然三萜类被认为是征服乳腺癌的有希望的药物。
Breast cancer is the most prevalent type of cancer, the fifth leading cause of cancer-related deaths, and the second leading cause of cancer deaths among women globally. Recent research has provided increasing support for the significance of phytochemicals, both dietary and non-dietary, particularly triterpenoids, in the mitigation and management of breast cancer. Recent studies showed that triterpenoids are promising agents in the treatment and inhibition of breast cancer achieved through the implementation of several molecular modes of action on breast cancer cells. This
review discusses recent innovations in plant triterpenoids and their underlying mechanisms of action in combating breast cancer within the timeframe spanning from 2017 to 2023. The present work is an overview of different plant triterpenoids with significant inhibition on proliferation, migration, apoptosis resistance, tumor angiogenesis, or metastasis in various breast cancer cells. The anticancer impact of triterpenoids may be attributed to their antiproliferative activity interfering with angiogenesis and differentiation, regulation of apoptosis, DNA polymerase inhibition, change in signal transductions, and impeding metastasis. The present
review focuses on several targets, mechanisms, and pathways associated with pentacyclic triterpenoids, which are responsible for their anticancer effects. We could conclude that natural triterpenoids are considered promising agents to conquer breast cancer.