目的:评价周边离焦眼镜片(PDL)在近视控制中的有效性。
方法:PubMed上的文献检索,科克伦图书馆,Embase,和WebofScience数据库,且检索时限为自各数据库建立至2021年12月29日进行。从符合纳入标准的文献中提取球面等效屈光度变化(SER)和轴向变化(AL),采用RevMan5.3软件进行Meta分析。
结果:本Meta分析共纳入4项随机对照试验,涉及770名近视儿童。结果表明,与单视眼镜片相比,PDL可以延迟近视儿童的近视进展(SVL;WMD=0.21D,95CI:0.01,0.41,P=0.04)。然而,在控制近视儿童的眼轴长度(AL)的增长方面没有显着差异(WMD=-0.10mm,95CI:-0.21,0.01,P=0.07)。两种眼镜片之间的近视控制有效性结果表明,PDL比SVL更有效地控制了近视的发展(OR=5.73,95CI:2.58,12.70,P<0.001)和延迟AL的增长(OR=44.25,95CI:8.84,221.58,P<0.001),差异有统计学意义。
结论:与SVL相比,PDL可以控制近视的进展,但不能延缓AL的增长,PDL在近视控制方面的有效性优于SVL。
OBJECTIVE: To evaluate the effectiveness of peripheral defocus spectacle lenses (PDLs) in myopia control.
METHODS: Literature retrieval on PubMed, Cochrane Library, Embase, and Web of Science databases, and the search time limit was from the establishment of each database to December 29, 2021 were conducted. Change of spherical equivalent refraction (SER) and axial change (AL) were extracted from the literatures that met the inclusion criteria, and RevMan5.3 software was used for Meta-analysis.
RESULTS: A total of 4 randomized controlled trials (RCTs) were included in this Meta-analysis, involving 770 myopic children. The results showed that PDLs could delay the progression of myopia in children with myopia compared with single vision spectacle lenses (SVLs; WMD=0.21 D, 95%CI: 0.01, 0.41, P=0.04). However, there was no significant difference in controlling the growth of axial length (AL) in myopic children (WMD=-0.10 mm, 95%CI: -0.21, 0.01, P=0.07). The results of the effectiveness of myopia control between the two spectacle lenses showed that PDLs were more effective in controlling the progression of myopia (OR=5.73, 95%CI: 2.58, 12.70, P<0.001) and delaying the growth of AL (OR=44.25, 95%CI: 8.84, 221.58, P<0.001) than SVLs, and the differences were statistically significant.
CONCLUSIONS: PDLs can control the progression of myopia compared with SVLs, but cannot delay the growth of AL, and the effectiveness of PDLs in myopia control better than SVLs.